Document Detail


Common quantitative trait loci for alcohol-related behaviors and central nervous system neurotensin measures: hypnotic and hypothermic effects.
MedLine Citation:
PMID:  9023306     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genetic correlations were found between high-affinity neurotensin receptor (NTR(H)) densities and NT-immunoreactivity (NT-ir) levels in specific brain regions and sensitivity to hypnotic and hypothermic effects of ethanol in LSXSS recombinant inbred strains of mice. Simple sequence length polymorphisms were used to identify quantitative trait loci (QTL) influencing hypnotic and hypothermic sensitivity to ethanol, NTR(H) and low-affinity neurotensin receptor densities and NT-ir levels in LSXSS recombinant inbred strains. Common QTL for NTR(H) receptor densities, NT-ir levels and these ethanol actions were identified. One of the QTL (chromosome 2, 80 cM) for NTR(H) density and hypnotic sensitivity is linked to the NTR(H) gene, Ntsr. Also, QTL for NTR(H) density were found in common with confirmed QTL for hypnotic sensitivity on chromosomes 1 (43 cM), 11 (57 cM) and 15 (56 cM) and with an unconfirmed QTL on chromosome 3 (19 cM). Two common QTL for NT-ir levels, but not NTR(H) or low-affinity neurotensin receptor receptors, and ethanol-induced hypothermia were observed on chromosomes 4 (43 cM) and 6 (41 cM). Two common QTL for NT-ir levels and sleep time were identified on chromosomes 3 (19 cM) and 9 (55 cM). Common QTL indicate that genes regulating NT receptor and/or NT-ir expression may be the same as those regulating sensitivity to ethanol.
Authors:
V G Erwin; P D Markel; T E Johnson; V M Gehle; B C Jones
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  280     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-03-17     Completed Date:  1997-03-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  911-8     Citation Subset:  IM    
Affiliation:
Alcohol Research Center and School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA.
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MeSH Terms
Descriptor/Qualifier:
Alcoholism / genetics*
Analgesics, Non-Narcotic / pharmacology*
Animals
Brain / metabolism*
Chromosome Mapping*
Ethanol / pharmacology*
Genetic Markers
Genotype
Hypnotics and Sedatives / pharmacology*
Male
Mice
Mice, Inbred Strains
Neurotensin / metabolism*
Polymorphism, Genetic*
Receptors, Neurotensin / genetics*,  metabolism
Recombination, Genetic
Grant Support
ID/Acronym/Agency:
AA 07330/AA/NIAAA NIH HHS; AA 08940/AA/NIAAA NIH HHS; AA03527/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Genetic Markers; 0/Hypnotics and Sedatives; 0/Receptors, Neurotensin; 39379-15-2/Neurotensin; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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