| Common misdiagnoses in lymphomas and avoidance strategies. | |
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MedLine Citation:
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PMID: 20227918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lymphoma diagnosis integrates clinical, morphological, immunophenotypical, and molecular genetic features, as shown in WHO classifications of lymphoid malignancies. Diagnosis of lymphoma is challenging. Reactive lesions such as Kikuchi lymphadenitis, infectious mononucleosis, autoimmune lymphoproliferative syndrome, and immunoglobulin G4-related sclerosing disease can be misdiagnosed as lymphomas. Anaplastic large-cell lymphoma variants that are positive for anaplastic lymphoma kinase, classical Hodgkin's lymphoma variants, and infarcted lymphomas might be misdiagnosed as reactive disorders. Difficulties with classification of lymphomas are also encountered, such as the distinction of classical Hodgkin's lymphoma from anaplastic large-cell lymphoma that is negative for anaplastic lymphoma kinase. Interpretation of immunophenotyping results is complicated in some cases by aberrant or cross-lineage expression of lymphoid antigens on lymphomas, and the occasional lymphoid antigen expression on non-lymphoid malignancies. Molecular analysis can help to define clonality and lineage, but can be affected by the sensitivity and specificity of tests and cross-lineage gene rearrangement and pseudoclonality. To resolve these issues, a close collaboration between the clinician, histopathologist, and molecular biologist is needed. The aim of this review is to provide pathologists and clinicians with a concise account of these pitfalls and avoidance strategies. |
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Authors:
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John K C Chan; Yok-Lam Kwong |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-03-12 |
Journal Detail:
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Title: The lancet oncology Volume: 11 ISSN: 1474-5488 ISO Abbreviation: Lancet Oncol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-06-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100957246 Medline TA: Lancet Oncol Country: England |
Other Details:
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Languages: eng Pagination: 579-88 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD20
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analysis Antigens, CD3 / analysis Diagnostic Errors* False Negative Reactions Gene Rearrangement Humans Immunophenotyping Lymphoma / classification, diagnosis*, genetics, pathology Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD20; 0/Antigens, CD3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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