| Common mechanisms in immune-mediated inflammatory disease. | |
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MedLine Citation:
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PMID: 15693110 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Characterization of the K/BxN mouse model of spontaneous arthritis contributed to the rediscovery of immune complex-mediated inflammation in rheumatoid arthritis (RA). Serum from these animals can transfer joint-specific inflammation to normal mice. Fc receptors, interleukin 1, mast cells, and complement are all essential for the development of arthritis after serum transfer. In RA, additional amplifying factors have been identified, including cytokines and intracellular signaling molecules, such as mitogen-activated protein kinases and nuclear factor kappa B, that perpetuate inflammation. Understanding the autoimmune and inflammatory pathways implicated in disease has led to targeted drug development and improved clinical outcomes. |
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Authors:
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Gary S Firestein; Maripat Corr |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Journal of rheumatology. Supplement Volume: 73 ISSN: 0380-0903 ISO Abbreviation: J Rheumatol Suppl Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-02-04 Completed Date: 2005-04-28 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7806058 Medline TA: J Rheumatol Suppl Country: Canada |
Other Details:
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Languages: eng Pagination: 8-13; discussion 29-30 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Allergy, and Immunology, Department of Medicine, University of California at San Diego, San Diego, California, USA. gfirestein@ucsd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arthritis, Experimental / enzymology, genetics, immunology* Arthritis, Rheumatoid / enzymology, genetics, immunology* Genetic Predisposition to Disease Glucose-6-Phosphate Isomerase / immunology Humans Immunization, Passive Mice Mice, Transgenic |
| Chemical | |
Reg. No./Substance:
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EC 5.3.1.9/Glucose-6-Phosphate Isomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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