| Common genomic variants associated with variation in plasma lipoproteins in young aboriginal Canadians. | |
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MedLine Citation:
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PMID: 9194755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We hypothesized that common genomic variants would be associated with variation in lipoprotein phenotypes in young subjects. We determined genotypes of FABP2, PON, APOC3, and APOE in 188 aboriginal Canadians, aged 9 to 17 years. We found that 13 of 32 possible genotype-phenotype associations were significant: (1) the FABP2 codon 54 genotype was associated with variation in plasma triglycerides (P = .045); (2) the PON codon 192 genotype was associated with variation in plasma total and LDL cholesterol and apoB (P = .0099, P = .0088, and P = .016, respectively); (3) the APOC3 insulin-response-element genotype was associated with variation in plasma triglycerides, HDL cholesterol, apoA-I, the total cholesterol to HDL cholesterol ratio, and the apoB to apoA-I ratio (P = .0014, P = .0069, P = .045, P = .0021, and P = .0081, respectively); and (4) the APOE restriction isotype was associated with variation in plasma LDL cholesterol, apoB, the total cholesterol to HDL cholesterol ratio, and the apoB to apoA-I ratio (P = .025, P = .034, P = .045, and P = .047, respectively). The average young age and relative absence of age-dependent secondary environmental factors could have eased the identification of small genetic effects on lipoprotein phenotypes in this study sample. |
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Authors:
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R A Hegele; P W Connelly; A J Hanley; F Sun; S B Harris; B Zinman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 17 ISSN: 1079-5642 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-07-10 Completed Date: 1997-07-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1060-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, St Michael's Hospital, Toronto, Ontario, Canada. robert.hegele@utoronto.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Alleles Apolipoprotein C-III Apolipoproteins C / genetics* Apolipoproteins E / genetics* Aryldialkylphosphatase Canada Carrier Proteins / genetics* Child Esterases / genetics* Fatty Acid-Binding Proteins Female Gene Frequency Genotype Humans Indians, North American / genetics* Lipoproteins / blood* Male Myelin P2 Protein / genetics* Neoplasm Proteins* Phenotype Tumor Suppressor Proteins* |
| Grant Support | |
ID/Acronym/Agency:
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91-DK-01/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein C-III; 0/Apolipoproteins C; 0/Apolipoproteins E; 0/Carrier Proteins; 0/FABP2 protein, human; 0/FABP7 protein, human; 0/Fabp2 protein, mouse; 0/Fatty Acid-Binding Proteins; 0/Lipoproteins; 0/Myelin P2 Protein; 0/Neoplasm Proteins; 0/Tumor Suppressor Proteins; EC 3.1.-/Esterases; EC 3.1.8.1/Aryldialkylphosphatase |
| Comments/Corrections | |
Erratum In:
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Arterioscler Thromb Vasc Biol 1997 Oct;17(10):2306 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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