Document Detail


Common genomic HLA haplotypes contributing to successful donor search in unrelated hematopoietic transplantation.
MedLine Citation:
PMID:  12665835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to identify the most frequent HLA haplotypes in order to optimize donor searches in unrelated hematopoietic stem cell (HSC) transplantation. Pediatric patients from the north of France who underwent initial HLA typing for donor search in our center were included. Patients and family members were broadly typed for HLA class I and II. Patients were further DNA typed at the sequence level for HLA-A, -B, -Cw, -DRB1, and -DQB1 alleles. In 200 of 207 patients HLA haplotypes were assigned by the mode of inheritance. The most common haplotypes were defined based on frequencies over 0.75%. Searches for unrelated donors were completed for 86 patients lacking a family donor. Matching criteria were either the optimal level of 10 alleles or a one-HLA class I mismatch as a second choice. Rates of successful search reach 85% for patients (n=20) who express at least one common five-allele (HLA-A/B/Cw/DRB1/DQB1) haplotype, but also 77% for more patients (n=53) who express at least one of the 20 most frequent three-allele (HLA-A/B/Cw) haplotypes. Success rates are clearly less (39%) in patients lacking these haplotypes. The use of these data to delineate search strategies is discussed.
Authors:
B Pedron; M Duval; O M Elbou; M Moskwa; M Jambou; E Vilmer; G Sterkers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  31     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-31     Completed Date:  2003-11-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  423-7     Citation Subset:  IM    
Affiliation:
Laboratoire d'Immunologie, Hôpital Robert Debré, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
France
Gene Frequency
HLA Antigens / genetics
HLA-B Antigens / genetics
HLA-C Antigens / genetics
Haplotypes
Hematopoietic Stem Cell Transplantation*
Histocompatibility Testing*
Humans
Registries
Tissue Donors
Tissue and Organ Procurement*
Waiting Lists
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/HLA-B Antigens; 0/HLA-C Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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