Document Detail


Common genetic variation in vitamin D metabolism is associated with liver stiffness.
MedLine Citation:
PMID:  22576297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Common variation in 25(OH)-vitamin D metabolism is associated with liver stiffness in patients presenting with low to moderately increased elasticity. Although the susceptible DHCR7 genotype confers small risk, we speculate that the observed stiffness differences indicate a stronger influence of 25(OH)-vitamin D on initiation rather than progression of hepatic fibrosis.
Authors:
Frank Grünhage; Katrin Hochrath; Marcin Krawczyk; Aksana Höblinger; Barbara Obermayer-Pietsch; Jürgen Geisel; Michael Trauner; Tilman Sauerbruch; Frank Lammert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-14
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  56     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-01     Completed Date:  2013-01-15     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1883-91     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
Affiliation:
Department of Medicine II, Saarland University Medical Center, Homburg, Germany. frank.gruenhage@uks.eu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Cholestanetriol 26-Monooxygenase / genetics*
Elasticity*
Elasticity Imaging Techniques
Female
Genetic Predisposition to Disease / genetics*
Heterozygote
Homozygote
Humans
Linear Models
Liver Cirrhosis / blood,  genetics*,  pathology
Male
Middle Aged
Multivariate Analysis
Oxidoreductases Acting on CH-CH Group Donors / genetics*
Polymorphism, Single Nucleotide
Statistics, Nonparametric
Vitamin D / analogs & derivatives*,  blood,  genetics
Vitamin D-Binding Protein / genetics
Young Adult
Chemical
Reg. No./Substance:
0/Vitamin D-Binding Protein; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D; EC 1.14.13.15/CYP2R1 protein, human; EC 1.14.13.15/Cholestanetriol 26-Monooxygenase; EC 1.3.-/Oxidoreductases Acting on CH-CH Group Donors; EC 1.3.1.21/7-dehydrocholesterol reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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