Document Detail

Common dopaminergic mechanism for epileptic photosensitivity in progressive myoclonus epilepsies.
MedLine Citation:
PMID:  2104965     Owner:  NLM     Status:  MEDLINE    
We studied the effect of apomorphine, a dopamine receptor agonist, on epileptic photosensitivity in 7 patients with progressive myoclonus epilepsy (PME). Specific diagnoses included Baltic PME (Unverricht-Lundborg disease), Lafora disease, Kufs' disease, juvenile neuroaxonal dystrophy, and action myoclonus-renal failure syndrome; 2 patients had PME of uncertain etiology. Apomorphine blocked the epileptic photosensitivity in all patients and also reduced intention myoclonus in a patient with Baltic PME. There is a common deficit of dopaminergic inhibitory neurotransmission at the level of the striate cortex in patients with PME, regardless of the nature of the specific underlying neuropathologic process.
E Mervaala; F Andermann; L F Quesney; M Krelina
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  40     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-16     Completed Date:  1990-02-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-6     Citation Subset:  AIM; IM    
Montreal Neurological Institute and Hospital, McGill University, Montreal, Québéc, Canada.
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MeSH Terms
Apomorphine / administration & dosage*
Epilepsies, Myoclonic / physiopathology*
Photosensitivity Disorders / physiopathology*
Reg. No./Substance:
Comment In:
Neurology. 1991 Apr;41(4):612   [PMID:  1901398 ]

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