Document Detail

Common carotid artery intima-media thickness determinants in a population study.
MedLine Citation:
PMID:  17384039     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Common carotid artery (CCA) intima-media thickness (IMT) is considered an atherosclerosis risk marker. Thickening of the intima-media complex is accelerated by vascular risk factors, in particular, by age and elevated blood pressure. Nonetheless, it also reflects intimal hyperplasia and intimal fibrocellular hypertrophy provoked by nonatherosclerotic mechanisms such as tensile wall stress. The aims of our study were to investigate the relationship between CCA IMT and the presence of vascular risk factors and to correlate CCA IMT with the degree of distal internal carotid artery (ICA) stenosis and the proximal CCA resistive index (RI), representative of wall stress. METHODS: We assessed CCA IMT, the CCA RI, and the presence of carotid plaques in 1655 consecutive patients. Demographic features and vascular risk factors were collected. RESULTS: A positive linear relationship between mean IMT and age was observed (R(2) = 0.27; P < .001). In the multiple stepwise regression model, the presence of ICA plaques and vascular risk factors were all independently associated with higher IMT. When considering IMT values for left and right sides separately, there was an independent relationship between CCA IMT and the lateralized percentage of ICA stenosis (right IMT-right ICA percentage, R(2) = 0.10; P < .0001; left IMT-left ICA percentage, R(2) = 0.16; P < .0001) and the CCA RI, even after correcting for age and vascular risk factors. CONCLUSIONS: Risk factors for atherosclerosis and the percentage of ICA stenosis were independently associated with higher IMT values and an increase in the RI. The synergic action of risk factors may cause further deterioration of mechanical forces independent of carotid atherosclerosis.
Edoardo Vicenzini; Maria Chiara Ricciardi; Francesco Puccinelli; Marta Altieri; Nicola Vanacore; Vittorio Di Piero; Gian Luigi Lenzi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  26     ISSN:  0278-4297     ISO Abbreviation:  J Ultrasound Med     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-26     Completed Date:  2007-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-32; quiz 434     Citation Subset:  IM    
Department of Neurological Sciences, University of Rome, La Sapienza, Viale dell' Università 30, 00185 Rome, Italy.
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MeSH Terms
Age Factors
Carotid Artery, Internal / pathology*,  ultrasonography
Carotid Stenosis / pathology*,  ultrasonography
Multivariate Analysis
Regression Analysis
Risk Factors
Tunica Intima / pathology*
Ultrasonography, Doppler, Color

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