Document Detail


Common aspects of human and primate seronegative arthritis.
MedLine Citation:
PMID:  15517649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 27-year-old female lowland gorilla developed an asymmetric oligoarthritis 3 months post-partum. There was no evidence of an antecedent gastrointestinal or genitourinary infection. Serum was negative for rheumatoid factor and antinuclear antibody. Synovial fluid revealed 2000 white blood cells with negative cultures and polarized microscopy. Studies on synoviocytes were the following: (1) FACS analysis revealed surface expression of a B27-like epitope of the cells. (2) Analysis of intracellular clearance kinetics of arthritogenic organisms showed peak intracellular colony-forming units at 48 hours after bacterial invasion, and clearance by 13 days post-invasion. (3) Interferon-y (0.1-10.0 ng/ml)accelerated intracellular microbicidal pathways in a dose-dependent fashion. These findings closely parallel those seen in human synoviocytes of patients with spondyloarthropathy. Primate and human seronegative arthritis share clinical and immunologic features, as well as aspects of host:pathogen defense mechanisms. The interplay of genetic and microbial factors underlying this arthritis appears to be conserved across these species boundaries.
Authors:
Kimme L Hyrich; Tae-Hwan Kim; Ursula Payne; Xiang Zhang; Basil Chiu; Kay Mehren; Robert D Inman
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  31     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-01     Completed Date:  2005-02-01     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  2300-4     Citation Subset:  IM    
Affiliation:
Division of Rheumatology, Toronto Western Hospital, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Ape Diseases / pathology*
Arthritis / pathology,  veterinary*
Cells, Cultured / drug effects,  microbiology
Colony Count, Microbial
Dose-Response Relationship, Drug
Flow Cytometry / veterinary
Gorilla gorilla*
Humans
Interferon-gamma / pharmacology
Kinetics
Salmonella typhimurium / drug effects,  physiology
Synovial Fluid / cytology,  microbiology
Synovial Membrane / drug effects,  microbiology,  pathology
Yersinia enterocolitica / drug effects,  physiology
Chemical
Reg. No./Substance:
82115-62-6/Interferon-gamma
Comments/Corrections
Comment In:
J Rheumatol. 2004 Nov;31(11):2102-3   [PMID:  15517618 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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