| Common Variants in Epithelial Sodium Channel Genes Contribute to Salt-Sensitivity of Blood Pressure: The GenSalt Study. | |
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MedLine Citation:
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PMID: 21562341 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: -Rare mutations of the epithelial sodium channel (ENaC) lead to Mendelian forms of salt-sensitive hypertension or salt-wasting hypotension. We aimed to examine the association between common variants in the ENaC genes and salt-sensitivity of blood pressure (BP). METHODS AND RESULTS: -A total of 1,906 Han Chinese participated in the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) study, which includes a 7-day low-sodium intake (51.3 mmol sodium/day) followed by a 7-day high-sodium intake (307.8 mmol sodium/day). Nine BP measurements were obtained at baseline and each intervention period using a random-zero sphygmomanometer. Single nucleotide polymorphisms (SNPs), both tagging and functional, from the three ENaC subunits, α, β, and γ (SCNN1A, SCNN1B, and SCNN1G), were genotyped. Multiple common SNPs in SCNN1G were significantly associated with BP response to low-sodium intervention (rs4073930, p=1.7×10(-5); rs4073291, p=1.1×10(-5); rs7404408, p=1.9×10(-5); rs5735, p=3.0×10(-4); rs4299163, p=0.004; and rs4499238, p=0.002) even after correcting for multiple testing. For example, under an additive model, the minor allele G of SNP rs4073291 was associated with 1.33 mmHg lower systolic BP (SBP) reduction during low-sodium intervention. CONCLUSIONS: -This large dietary sodium intervention study indicates that common variants of ENaC subunits may contribute to the variation of BP response to dietary sodium intake. Future studies are warranted to confirm these findings in an independent population and to identify functional variants for salt-sensitivity. Clinical Trial Registration Information-http://clinicaltrials.gov; Identifier: NCT00721721. |
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Authors:
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Qi Zhao; Dongfeng Gu; James E Hixson; De-Pei Liu; Dabeeru C Rao; Cashell E Jaquish; Tanika N Kelly; Fanghong Lu; Jixiang Ma; Jianjun Mu; Lawrence C Shimmin; Jichun Chen; Hao Mei; L Lee Hamm; Jiang He |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-11 |
Journal Detail:
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Title: Circulation. Cardiovascular genetics Volume: - ISSN: 1942-3268 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101489144 Medline TA: Circ Cardiovasc Genet Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Tulane University School of Public Health & School of Medicine, New Orleans, LA; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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