| Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age. | |
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MedLine Citation:
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PMID: 20045156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insulin-induced gene 2 (INSIG2) plays an important role in the regulation of cholesterol and fatty acids synthesis. A polymorphism, rs7566605, located 10 kilobases upstream of the INSIG2 gene, was identified in a genomewide association study of obesity. We conducted an association study of 12 INSIG2 tag-single nucleotide polymorphisms with longitudinal measures of body size (body mass index and waist circumference) and lipid metabolism (plasma high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides levels). We investigated their interaction with age in 4304 Coronary Artery Risk Development in Young Adults participants (49.5% blacks, 50.5% whites) followed prospectively for 20 years. rs7566605 was not associated with variation in body size or lipid metabolism at any age in either racial group. However, rs1352083 and rs10185316 were associated with age-related decline in high-density lipoprotein cholesterol in whites (P = .0005 and .04, respectively). A similar trend was observed in blacks who consistently maintained a body mass index less than 25 kg/m(2) over the study period. These data support a role of INSIG2 sequence variation in the regulation of cholesterol metabolism. |
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Authors:
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Myriam Fornage; George Papanicolaou; Cora E Lewis; Eric Boerwinkle; David S Siscovick |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-12-31 |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 59 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-08-11 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 1084-91 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, TX, USA. myriam.fornage@uth.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Body Mass Index Body Size* Cholesterol, HDL / blood* Cross-Sectional Studies Female Humans Intracellular Signaling Peptides and Proteins / genetics* Male Membrane Proteins / genetics* Polymorphism, Single Nucleotide* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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N01-HC-48047/HC/NHLBI NIH HHS; N01-HC-48048/HC/NHLBI NIH HHS; N01-HC-48049/HC/NHLBI NIH HHS; N01-HC-48050/HC/NHLBI NIH HHS; N01-HC-95095/HC/NHLBI NIH HHS; R01 HL084099-01A1/HL/NHLBI NIH HHS; R01 HL084099-02/HL/NHLBI NIH HHS; R01 HL084099-03/HL/NHLBI NIH HHS; R01-HL69126/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/INSIG2 protein, human; 0/Intracellular Signaling Peptides and Proteins; 0/Membrane Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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