| Comminution of carbohydrate and protein microparticles on firing in a ballistic powder injector. | |
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MedLine Citation:
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PMID: 20575004 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The comminution of various powders produced by either spray-freeze-drying (SFD) or spray-drying (SD) on firing in a Ballistic powder injector could be evaluated quantitatively using light microscopic particle imaging. SFD lactose was damaged much less than SFD mannitol and was caused by greater mechanical strength and lower acceleration. SD lactose or mannitol showed much reduced comminution because of their low porosity. SFD lactose/mannitol/dextran 10 kDa formulations also showed less low comminution. The inclusion of catalase further reduced damage on firing. The extent of comminution on firing was found to be related to microparticle surface structure and porosity which influences both mechanical strength and acceleration. |
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Authors:
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Andreas Ziegler; Sonja Simon; Geoffrey Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 99 ISSN: 1520-6017 ISO Abbreviation: J Pharm Sci Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: United States |
Other Details:
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Languages: eng Pagination: 4917-27 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley-Liss, Inc. and the American Pharmacists Association |
Affiliation:
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Division of Pharmaceutics, Friedrich-Alexander-University Erlangen, Erlangen, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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