Document Detail

Comments on "endpoints in hypertension": peripheral resistance vessels--though mainly on their involvement as "starting-points".
MedLine Citation:
PMID:  9495624     Owner:  NLM     Status:  MEDLINE    
In SHR, and probably often in human primary hypertension as well, the structural-geometric changes in proximal resistance arteries (r(i) decrease combined with w/r(i) increase) seem to occur so early in life, and are already then so pronounced, that they must serve also as major "starting-points" for this disorder of regulation, besides contributing to late deterioration and "end-point" situations by increasingly interfering with myocardial, cerebral, renal etc. blood supplies, and hence functions. Furthermore, particularly in early phases of primary hypertension they may have some easily overlooked influences on evaluations of average vascular smooth muscle activity, and of overall haemodynamics as well, which is briefly discussed.
B Folkow
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Blood pressure. Supplement     Volume:  2     ISSN:  0803-8023     ISO Abbreviation:  Blood Press Suppl     Publication Date:  1997  
Date Detail:
Created Date:  1998-04-20     Completed Date:  1998-04-20     Revised Date:  2008-02-26    
Medline Journal Info:
Nlm Unique ID:  9300787     Medline TA:  Blood Press Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  34-8     Citation Subset:  IM    
Department of Physiology and Pharmacology, University of Göteborg, Sweden.
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MeSH Terms
Blood Vessels / pathology,  physiopathology
Hypertension / pathology*,  physiopathology
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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