Document Detail


Commentary on resveratrol and hormesis: resveratrol--a hormetic marvel in waiting?
MedLine Citation:
PMID:  21115564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hormesis is a phenomenon in which adaptive responses to low doses of otherwise-harmful factors (also called mild stressors) make cells and organisms more robust. In their review, Calabrese et al. provide evidence for resveratrol acting hormetically in different types of human cell lines. The effects of resveratrol represent a 'two-edged sword' in that it has contrasting effects at low and high doses in healthy and cancerogenous cells. What demarcates a low and a high dose needs to be clarified. Concentrations tested in cell cultures, moreover, may not be relevant to whole organisms. And data from animal models need not apply to humans. Co-morbidities should also be considered. More research is needed to understand the action of resveratrol on all cell types and conditions, and the optimum therapeutic concentration that applies to each of these. Future research needs to determine the dynamics of the effects of resveratrol in different subcellular compartments and the interactions of these. In addition, the interactions between resveratrol, environmental factors, other compounds and medications, diseases and the genetic background of the individual will need to be appreciated in order to gain a complete understanding of the hormetic response of resveratrol.
Authors:
Francine Z Marques; Brian J Morris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  29     ISSN:  1477-0903     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-30     Completed Date:  2011-03-11     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1026-8     Citation Subset:  IM    
Affiliation:
Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, Anderson Stuart Building, University of Sydney, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Availability
Biomedical Research* / methods,  standards
Dose-Response Relationship, Drug*
Humans
Nonprescription Drugs / standards
Solubility
Stilbenes / administration & dosage*,  adverse effects,  pharmacokinetics,  pharmacology
Chemical
Reg. No./Substance:
0/Nonprescription Drugs; 0/Stilbenes; Q369O8926L/resveratrol
Comments/Corrections
Comment In:
Hum Exp Toxicol. 2011 Dec;30(12):2027-30   [PMID:  21558146 ]
Hum Exp Toxicol. 2010 Dec;29(12):980-1015   [PMID:  21115559 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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