| Special issue on in vitro MN trial. | |
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MedLine Citation:
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PMID: 20654729 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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In this commentary we are addressing some additional thoughts on the in vitro MN test: its predictivity for in vivo MN assays, its sensitivity, and how the choice of the cell line and the protocol (with or without cytochalasin-B) can influence these aspects. These considerations might help to make the in vitro MN test a reliable, toxicologically relevant and sensitive in vitro genotoxicity test covering both clastogenic and aneugenic events, and predictive for in vivo genotoxicity, in humans as well. |
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Authors:
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James M Parry; Micheline Kirsch-Volders |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-21 |
Journal Detail:
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Title: Mutation research Volume: 702 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2011-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 132-4 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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School of Medicine, University of Wales-Swansea, Swansea, United Kingdom. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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