Document Detail

Comment on "Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery".
MedLine Citation:
PMID:  17626868     Owner:  NLM     Status:  MEDLINE    
Tyzio et al. (Reports, 15 December 2006, p. 1788) reported that maternal oxytocin triggers a transient excitatory-to-inhibitory switch of gamma-aminobutyric acid (GABA) signaling during labor, thus protecting the fetal rat brain from anoxic injury. However, a body of evidence supports the possibility that oxytocin is released from the fetal pituitary during delivery, not only from the mother, particularly under conditions of hypoxic stress.
Lionel Carbillon
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  317     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-13     Completed Date:  2007-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  197; author reply 197     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Assistance Publique-Hôpitaux de Paris, Paris 13 University, Hôpital Jean Verdier, Avenue du 14 Juillet, 93143 Bondy Cedex, France.
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MeSH Terms
Animals, Newborn
Brain / embryology*,  metabolism
Fetal Hypoxia / physiopathology,  prevention & control
Fetus / metabolism*
Hippocampus / embryology,  metabolism
Oxytocin / metabolism,  physiology*
Pituitary Gland / embryology,  metabolism
Signal Transduction*
gamma-Aminobutyric Acid / metabolism*
Reg. No./Substance:
50-56-6/Oxytocin; 56-12-2/gamma-Aminobutyric Acid
Comment On:
Science. 2006 Dec 15;314(5806):1788-92   [PMID:  17170309 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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