Document Detail


Commensal bacteria and cutaneous immunity.
MedLine Citation:
PMID:  25326105     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The skin is the human body's largest organ and is home to a diverse and complex variety of innate and adaptive immune functions that protect against pathogenic invasion. Recent studies have demonstrated that cutaneous commensal bacteria modulated the host immune system. For example, Staphylococcus epidermidis, a skin commensal bacterium, has been demonstrated to induce cutaneous interferon (IFN)-γ- and interleukin (IL)-17A-producing T cells. In addition, cutaneous microbiota changes occur in the chronic inflammatory skin disorders, such as atopic dermatitis, and may influence the activity of skin diseases. In this article, we will review the recent findings related to the interactions of the commensal bacteria with skin homeostasis and discuss the role of the dysbiosis of these bacteria in the pathogenesis of skin diseases.
Authors:
Satoshi Nakamizo; Gyohei Egawa; Tetsuya Honda; Saeko Nakajima; Yasmine Belkaid; Kenji Kabashima
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-18
Journal Detail:
Title:  Seminars in immunopathology     Volume:  -     ISSN:  1863-2300     ISO Abbreviation:  Semin Immunopathol     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-18     Completed Date:  -     Revised Date:  2014-10-19    
Medline Journal Info:
Nlm Unique ID:  101308769     Medline TA:  Semin Immunopathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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