| Commensal Microflora Contribute to Host Defense Against E.coli Pneumonia Through Toll-Like Receptors. | |
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MedLine Citation:
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PMID: 21412185 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The influence of the gut-lung axis on the lung immunity while appreciate, remains undefined mechanically. This study was designed to investigate whether commensal microflora in gut increase host defense against subsequent pneumonia through TLR signaling, and if oral TLR4 ligand supplementation enhances lung defense against bacterial challenge. We found that commensal gut depletion by antibiotic pretreatment before E.coli pneumonia challenge induced a 15-fold and a 3-fold increase in bacterial counts in blood and lung, respectively, and a 30% increase of mortality when compared with the E.coli group. Commensal depletion also induced a suppression of cytokines expression as well as NF-κB activity in intestine. Furthermore, LPS supplementation during antibiotic pretreatment reversed these effects. Commensal depletion also decreased bacterial killing activity of alveolar macrophages and increased IL-6 as well as IL-1β levels and KC, MIP-2, IL-1β expression of lung and LPS supplementation reversed them. In conclusion, commensal gut microflora in the intestinal tract appear to be critical in inducing TLR4 expression as well as NF-κB activation of intestine, and lung innate defense against E.coli pneumonia. |
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Authors:
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Lee-Wei Chen; Pei-Hsuan Chen; Ching-Mei Hsu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-15 |
Journal Detail:
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Title: Shock (Augusta, Ga.) Volume: - ISSN: 1540-0514 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421564 Medline TA: Shock Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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#Institute of Emergency and Critical Care Medicine, National Yang-Ming University, Taipei, #Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung; δDepartment of Biological Sciences, National Sun Yat-Sen University, Kaohsiung; Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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