| Coming full circle in diabetes mellitus: from complications to initiation. | |
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MedLine Citation:
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PMID: 23296171 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Glycaemic control, reduction of blood pressure using agents that block the renin-angiotensin system and control of dyslipidaemia are the major strategies used in the clinical management of patients with diabetes mellitus. Each of these approaches interrupts a number of pathological pathways, which directly contributes to the vascular complications of diabetes mellitus, including renal disease, blindness, neuropathy and cardiovascular disease. However, research published over the past few years has indicated that many of the pathological pathways important in the development of the vascular complications of diabetes mellitus are equally relevant to the initiation of diabetes mellitus itself. These pathways include insulin signalling, generation of cellular energy, post-translational modifications and redox imbalances. This Review will examine how the development of diabetes mellitus has come full circle from initiation to complications and suggests that the development of diabetes mellitus and the progression to chronic complications both require the same mechanistic triggers. |
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Authors:
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Brooke E Harcourt; Sally A Penfold; Josephine M Forbes |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-08 |
Journal Detail:
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Title: Nature reviews. Endocrinology Volume: - ISSN: 1759-5037 ISO Abbreviation: Nat Rev Endocrinol Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101500078 Medline TA: Nat Rev Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Glycation and Diabetes Complications, Mater Medical Research Institute, Level 3, Aubigny Place, Raymond Terrace, South Brisbane, QLD 4101, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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