| Coming full circle: contributions of central and peripheral oxytocin actions to energy balance. | |
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MedLine Citation:
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PMID: 23270805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The neuropeptide oxytocin has emerged as an important anorexigen in the regulation of energy balance. Its effects on food intake have largely been attributed to limiting meal size through interactions in key regulatory brain regions such as the hypothalamus and hindbrain. Pharmacologic and pair-feeding studies indicate that its ability to reduce body mass extends beyond that of food intake, affecting multiple factors that determine energy balance such as energy expenditure, lipolysis, and glucose regulation. Systemic administration of oxytocin recapitulates many of its effects when administered centrally, raising the questions of whether and to what extent circulating oxytocin contributes to energy regulation. Its therapeutic potential to treat metabolic conditions remains to be determined, but data from diet-induced and genetically obese rodent models as well as application of oxytocin in humans in other areas of research have revealed promising results thus far. |
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Authors:
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Jacqueline M Ho; James E Blevins |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2012-12-27 |
Journal Detail:
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Title: Endocrinology Volume: 154 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-22 Completed Date: 2013-03-19 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 589-96 Citation Subset: AIM; IM |
Affiliation:
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Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA. jmh529@uw.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Eating / drug effects Energy Metabolism / drug effects* Humans Hypothalamus / physiology Mice Obesity / drug therapy Oxytocin / pharmacology*, physiology Paraventricular Hypothalamic Nucleus / secretion Rats Receptors, Oxytocin / genetics |
| Grant Support | |
ID/Acronym/Agency:
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T32DK007247-35/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Oxytocin; 50-56-6/Oxytocin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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