Document Detail


Coming full circle: contributions of central and peripheral oxytocin actions to energy balance.
MedLine Citation:
PMID:  23270805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The neuropeptide oxytocin has emerged as an important anorexigen in the regulation of energy balance. Its effects on food intake have largely been attributed to limiting meal size through interactions in key regulatory brain regions such as the hypothalamus and hindbrain. Pharmacologic and pair-feeding studies indicate that its ability to reduce body mass extends beyond that of food intake, affecting multiple factors that determine energy balance such as energy expenditure, lipolysis, and glucose regulation. Systemic administration of oxytocin recapitulates many of its effects when administered centrally, raising the questions of whether and to what extent circulating oxytocin contributes to energy regulation. Its therapeutic potential to treat metabolic conditions remains to be determined, but data from diet-induced and genetically obese rodent models as well as application of oxytocin in humans in other areas of research have revealed promising results thus far.
Authors:
Jacqueline M Ho; James E Blevins
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-12-27
Journal Detail:
Title:  Endocrinology     Volume:  154     ISSN:  1945-7170     ISO Abbreviation:  Endocrinology     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-22     Completed Date:  2013-03-19     Revised Date:  2014-04-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  589-96     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Eating / drug effects
Energy Metabolism / drug effects*
Humans
Hypothalamus / physiology
Mice
Obesity / drug therapy
Oxytocin / pharmacology*,  physiology
Paraventricular Hypothalamic Nucleus / secretion
Rats
Receptors, Oxytocin / genetics
Grant Support
ID/Acronym/Agency:
T32 DK007247/DK/NIDDK NIH HHS; T32DK007247-35/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Oxytocin; 50-56-6/Oxytocin
Comments/Corrections

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