| Come FLY with us: toward understanding fragile X syndrome. | |
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MedLine Citation:
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PMID: 16098136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The past few years have seen an increased number of articles using Drosophila as a model system to study fragile X syndrome. Phenotypic analyses have demonstrated an array of neuronal and behavioral defects similar to the phenotypes reported in mouse models as well as human patients. The availability of both cellular and molecular tools along with the power of genetics makes the tiny fruit fly a premiere model in elucidating the molecular basis of fragile X syndrome. Here, we summarize the advances made in recent years in the characterization of fragile X Drosophila models and the identification of new molecular partners in neural development. |
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Authors:
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D C Zarnescu; G Shan; S T Warren; P Jin |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Genes, brain, and behavior Volume: 4 ISSN: 1601-1848 ISO Abbreviation: Genes Brain Behav. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-15 Completed Date: 2005-10-03 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 101129617 Medline TA: Genes Brain Behav Country: England |
Other Details:
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Languages: eng Pagination: 385-92 Citation Subset: IM |
Affiliation:
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Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Drosophila Proteins / genetics*, metabolism Drosophila melanogaster / embryology, genetics*, metabolism Fragile X Mental Retardation Protein Fragile X Syndrome / genetics*, metabolism, physiopathology Gametogenesis / genetics Gonads / cytology, embryology, metabolism Humans MicroRNAs / metabolism Nervous System / embryology*, metabolism RNA, Messenger / metabolism RNA-Binding Proteins / genetics*, metabolism Synaptic Transmission / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/FMR1 protein, Drosophila; 0/MicroRNAs; 0/RNA, Messenger; 0/RNA-Binding Proteins; 139135-51-6/Fragile X Mental Retardation Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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