Document Detail

Combining sirolimus-eluting stents and external irradiation in cholesterol-fed rabbits increased incomplete stent apposition and decreased re-endothelialization.
MedLine Citation:
PMID:  19295445     Owner:  NLM     Status:  MEDLINE    
Restenosis after the implantation of a drug-eluting stent or after vascular irradiation therapy shares similar physiopathological mechanisms. No experimental data are currently available on vascular wall behavior after external irradiation on arteries stented with sirolimus-eluting stents (SES). Ten New Zealand white rabbits received a 0.5% cholesterol-enriched chow for 1 month. Bilateral iliac artery stent implantation was then performed with an SES (Cypher; Cordis Corp). The animals were randomized into either an irradiated group (I, 2 Gy external x-ray irradiation, n = 5) or a control group (C, n = 5). The cholesterol-enriched chow was continued for 1 additional month after stent implantation. The stented arteries were harvested for histological analyses. The number and the percentage of incompletely apposed stents struts (IASS) were significantly higher in irradiated versus control group (3.05 +/- 0.46 vs. 1.57 +/- 0.27 IASS, P < 0.01, and 28.44% +/- 3.97% vs. 15.2% +/- 2.46% of IASS, P < 0.01, respectively). The mean neointimal thickness behind the IASS was also higher in the irradiated group (I: 28.3 +/- 2.5 microm vs. C: 18.2 +/- 2.3 microm, P < 0.01). Re-endothelialization was lower in irradiated group (I: 44.6% +/- 17.5% vs. C: 75.2% +/- 5.7%, P < 0.01). The present study revealed that low-dose external irradiation increased incomplete stent apposition and reduced re-endothelialization of SES. These results underscore the potential deleterious cumulative side effects of these 2 procedures to prevent restenosis.
David Busseuil; Bertrand Collin; Gilles Rioufol; Claudia Korandji; Marianne Zeller; Philippe Maingon; François Briot; Yves Cottin; Luc Rochette
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  53     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-27     Completed Date:  2009-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  318-24     Citation Subset:  IM    
Laboratory of Cardiovascular and Experimental Physiopathology and Pharmacology, Faculties of Medicine and Pharmacy, University of Burgundy, Dijon, France.
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MeSH Terms
Cholesterol / blood
Cholesterol, Dietary / administration & dosage
Dose-Response Relationship, Radiation
Drug-Eluting Stents / adverse effects*
Endothelium, Vascular / drug effects*,  radiation effects*,  ultrastructure
Immunosuppressive Agents / pharmacology*
Sirolimus / pharmacology*
Time Factors
Tunica Intima / radiation effects
Tunica Media / radiation effects
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Immunosuppressive Agents; 53123-88-9/Sirolimus; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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