| Combining short-term metformin treatment and one bout of exercise does not increase insulin action in insulin-resistant individuals. | |
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MedLine Citation:
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PMID: 20071560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Results from the Diabetes Prevention Program highlight the effectiveness of metformin or regular physical activity in the prevention of type 2 diabetes. Independently, metformin and exercise increase insulin sensitivity, but they have not been studied in combination. To assess the combined effects, insulin-resistant subjects (n = 9) matched for weight, body fat, and aerobic fitness were studied before any treatment (B), after 2-3 wk of 2,000 mg/day metformin (MET), and after metformin plus 40 min of exercise at 65% Vo(2peak) (MET + Ex). A second group (n = 7) was studied at baseline and after an identical bout of exercise with no metformin (Ex). Biopsies of the vastus lateralis were taken at B, after MET, immediately after MET + Ex (group 1), or immediately after Ex (group 2). Insulin sensitivity was assessed 4 h postexercise with a euglycemic hyperinsulinemic (40 mU.m(2).min(-1)) clamp enriched with [6,6-(2)H]glucose. Insulin sensitivity was 54% higher after Ex (P < 0.01), but there was no change with Met + Ex. Skeletal muscle AMPKalpha2 activity was elevated threefold (P < 0.01) after Ex, but there was no increase with MET + Ex. These findings suggest that the combination of short-term metformin treatment and an acute bout of exercise does not enhance insulin sensitivity, and the addition of metformin may attenuate the well-documented effects of exercise alone. |
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Authors:
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Carrie G Sharoff; Todd A Hagobian; Steven K Malin; Stuart R Chipkin; Haiyan Yu; Michael F Hirshman; Laurie J Goodyear; Barry Braun |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-01-13 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 298 ISSN: 1522-1555 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-04-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E815-23 Citation Subset: IM |
Affiliation:
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Department of Kinesiology, University of Massachusetts Amherst, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AMP-Activated Protein Kinases
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metabolism Adult Blotting, Western Exercise / physiology* Female Glucose Clamp Technique Heart Rate / physiology Humans Hypoglycemic Agents / pharmacology* Insulin / pharmacology*, physiology* Insulin Resistance / physiology* Lactic Acid / blood Male Metformin / pharmacology* Middle Aged Muscle, Skeletal / metabolism Oxygen Consumption / drug effects Phosphorylation |
| Grant Support | |
ID/Acronym/Agency:
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R01-DK-068626/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 11061-68-0/Insulin; 50-21-5/Lactic Acid; 657-24-9/Metformin; EC 2.7.11.1/AMP-Activated Protein Kinases; EC 2.7.11.1/AMPK alpha2 subunit, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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