Document Detail


Combining short-term metformin treatment and one bout of exercise does not increase insulin action in insulin-resistant individuals.
MedLine Citation:
PMID:  20071560     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Results from the Diabetes Prevention Program highlight the effectiveness of metformin or regular physical activity in the prevention of type 2 diabetes. Independently, metformin and exercise increase insulin sensitivity, but they have not been studied in combination. To assess the combined effects, insulin-resistant subjects (n = 9) matched for weight, body fat, and aerobic fitness were studied before any treatment (B), after 2-3 wk of 2,000 mg/day metformin (MET), and after metformin plus 40 min of exercise at 65% Vo(2peak) (MET + Ex). A second group (n = 7) was studied at baseline and after an identical bout of exercise with no metformin (Ex). Biopsies of the vastus lateralis were taken at B, after MET, immediately after MET + Ex (group 1), or immediately after Ex (group 2). Insulin sensitivity was assessed 4 h postexercise with a euglycemic hyperinsulinemic (40 mU.m(2).min(-1)) clamp enriched with [6,6-(2)H]glucose. Insulin sensitivity was 54% higher after Ex (P < 0.01), but there was no change with Met + Ex. Skeletal muscle AMPKalpha2 activity was elevated threefold (P < 0.01) after Ex, but there was no increase with MET + Ex. These findings suggest that the combination of short-term metformin treatment and an acute bout of exercise does not enhance insulin sensitivity, and the addition of metformin may attenuate the well-documented effects of exercise alone.
Authors:
Carrie G Sharoff; Todd A Hagobian; Steven K Malin; Stuart R Chipkin; Haiyan Yu; Michael F Hirshman; Laurie J Goodyear; Barry Braun
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-01-13
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  298     ISSN:  1522-1555     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-22     Completed Date:  2010-04-13     Revised Date:  2013-12-23    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E815-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
AMP-Activated Protein Kinases / metabolism
Adult
Blotting, Western
Exercise / physiology*
Female
Glucose Clamp Technique
Heart Rate / physiology
Humans
Hypoglycemic Agents / pharmacology*
Insulin / pharmacology*,  physiology*
Insulin Resistance / physiology*
Lactic Acid / blood
Male
Metformin / pharmacology*
Middle Aged
Muscle, Skeletal / metabolism
Oxygen Consumption / drug effects
Phosphorylation
Grant Support
ID/Acronym/Agency:
R01-DK-068626/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Hypoglycemic Agents; 0/Insulin; 33X04XA5AT/Lactic Acid; 9100L32L2N/Metformin; EC 2.7.11.1/AMP-Activated Protein Kinases; EC 2.7.11.1/AMPK alpha2 subunit, mouse
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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