Document Detail

Combining peak oxygen consumption and ventilatory efficiency in the prognostic assessment of patients with heart failure.
MedLine Citation:
PMID:  17306899     Owner:  NLM     Status:  MEDLINE    
Exercise ventilatory efficiency (VE/VCO2 slope) and peak oxygen consumption (VO2) are strong mortality predictors in patients with heart failure and we combined these 2 variables' beta coefficients from Cox regression to investigate a new prognostic index. Average follow-up was 3.8+/-1.8 years for 355 patients (72% male, 51+/-10 years). The beta coefficients from peak VO2 (17.3+/-5.0 ml x kg(-1) x min(-1)) and VE/VCO2 slope (37.0+/-9.0) constructed an exercise index defined as one half the peak VO2 subtracted from one fifth of the VE/VCO2 slope. The mean index was -1.14+/-3.79 and a more positive index was always associated with a higher probability of death. Patients with extremely poor prognoses were identified equally well by the index and by individual thresholds for peak VO2 (<14 ml x kg(-1) x min(-1)) and of VE/VCO2 slope (>40). In conclusion, the index did not add additional prognostic information in this cohort but it did display the prognostic superiority of VE/VCO2 slope.
Robert L Bard; Brenda W Gillespie; Nicholas S Clarke; John M Nicklas
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Publication Detail:
Type:  Letter     Date:  2007-02-16
Journal Detail:
Title:  International journal of cardiology     Volume:  123     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-18     Completed Date:  2008-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  199-200     Citation Subset:  IM    
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MeSH Terms
Heart Failure / metabolism*,  physiopathology*
Middle Aged
Oxygen Consumption*
Respiratory Mechanics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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