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Combining nuclear magnetic resonance spectroscopy and mass spectrometry in biomarker discovery.
MedLine Citation:
PMID:  20477478     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Metabolic profiling of biological specimens is emerging as a promising approach for discovering specific biomarkers in the diagnosis of a number of diseases. Amongst many analytical techniques, nuclear magnetic resonance spectroscopy and mass spectrometry are the most information-rich tools that enable high-throughput and global analysis of hundreds of metabolites in a single step. Although only one of the two techniques is utilized in a majority of metabolomics applications, there is a growing interest in combining the data from the two methods to effectively unravel the mammoth complexity of biological samples. In this article, current developments in nuclear magnetic resonance, mass spectrometry and multivariate statistical analysis methods are described. While some general applications that utilize the combination of the two analytical methods are presented briefly, the emphasis is laid on the recent applications of nuclear magnetic resonance and mass spectrometry methods in the studies of hepatopancreatobiliary and gastrointestinal malignancies.
Authors:
G A Nagana Gowda; Omkar B Ijare; Narasimhamurthy Shanaiah; Tedros Bezabeh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomarkers in medicine     Volume:  3     ISSN:  1752-0371     ISO Abbreviation:  Biomark Med     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312535     Medline TA:  Biomark Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  307-22     Citation Subset:  -    
Affiliation:
Analytical Division, Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. ngowda@purdue.edu
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