Document Detail

Combining nefazodone and midazolam during ECT.
MedLine Citation:
PMID:  10572373     Owner:  NLM     Status:  MEDLINE    
We report the case of a patient suffering from dysthymia. He underwent successful ECT treatment and was medicated with nefazodone and midazolam. Comparing the EEG and motor seizure duration in the periods with and without midazolam, no significant differences were recorded, but the dosage of thiopental and of succinylcholine had to be increased markedly after midazolam was discontinued (P < 0.05; ANOVA). This case indicates a substantial pharmacodynamic interaction between nefazodone, midazolam, thiopental, and succinylcholine.
A Conca; Z al-Dubai; P König; W Beraus
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European psychiatry : the journal of the Association of European Psychiatrists     Volume:  14     ISSN:  0924-9338     ISO Abbreviation:  Eur. Psychiatry     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-12-21     Completed Date:  1999-12-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9111820     Medline TA:  Eur Psychiatry     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  360-2     Citation Subset:  IM    
Department of Psychiatry I, Regional Hospital Rankweil, Austria.
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MeSH Terms
Antidepressive Agents, Second-Generation / therapeutic use*
Combined Modality Therapy
Drug Interactions
Dysthymic Disorder / therapy*
Electroconvulsive Therapy / methods*
Hypnotics and Sedatives / therapeutic use*
Midazolam / therapeutic use*
Middle Aged
Neuromuscular Depolarizing Agents / therapeutic use
Succinylcholine / therapeutic use
Thiopental / therapeutic use
Treatment Outcome
Triazoles / therapeutic use*
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Hypnotics and Sedatives; 0/Neuromuscular Depolarizing Agents; 0/Triazoles; 306-40-1/Succinylcholine; 59467-70-8/Midazolam; 76-75-5/Thiopental; 83366-66-9/nefazodone

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