Document Detail


Combining chronic kidney disease with 201thallium/123iodine beta methyliodophenyl pentadecanoic acid dual myocardial single-photon emission computed tomography findings is useful for the evaluation of cardiac event risk.
MedLine Citation:
PMID:  19306514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Chronic kidney disease is a noteworthy pathophysiology as a risk factor of cardiovascular disease. We investigated the usefulness of combining glomerular filtration rate and 201thallium(201TI)/123iodine-beta-methyliodophenyl pentadecanoic acid (123I-BMIPP) dual myocardial scintigraphic findings for predicting cardiac events. METHODS: Seventy-five patients suspected of coronary artery disease underwent 201TI/123I-BMIPP dual myocardial scintigraphy. Clinical and nuclear variables were included in the multivariate analysis for predicting hard events (cardiac death and nonfatal myocardial infarction) and soft events (unstable angina, heart failure, and coronary revascularization). Glomerular filtration rate was estimated by the modification of diet in renal disease formula. Kaplan-Meier analysis was performed to investigate the incremental prognostic value of glomerular filtration rate. RESULTS: During the mean follow-up period of 425 days, eight patients had hard events and 20 patients had soft events. Multivariate analysis revealed that glomerular filtration rate and the sum of total defect score in 123I-BMIPP image were independent predictors of total cardiac events, whereas sex, diabetes, glomerular filtration rate, and the number of abnormal segments in 201TI image were those of hard events. Kaplan-Meier analysis revealed that greater risk stratification was achieved by adding a glomerular filtration rate of lesser than 60 ml/min/1.73 m2 to the sum of the total defect score > or = 5 in the 123I-BMIPP image. Greater risk stratification for hard events was also achieved by adding a glomerular filtration rate of lesser than 30 ml/min/1.73 m2 to the number of abnormal segments > or = 2 in 201TI image. CONCLUSION: Better risk stratification can be achieved by adding glomerular filtration rate to 201TI/123I-BMIPP dual myocardial scintigraphic findings.
Authors:
Takeshi Takamura; Nobukazu Takahashi; Tomoaki Ishigami; Teruyasu Sugano; Toshiyuki Ishikawa; Kazuaki Uchino; Kazuo Kimura; Tomio Inoue; Satoshi Umemura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  30     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-03-23     Completed Date:  2009-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  54-61     Citation Subset:  IM    
Affiliation:
Yokohama City University, Graduate School of Medicine, Department of Cardiorenal Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama City, Kanagawa-pref., 236-0004, Japan. tkmrt@yokohama-cu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Chronic Disease
Fatty Acids / diagnostic use*
Female
Follow-Up Studies
Glomerular Filtration Rate
Heart / radionuclide imaging*
Heart Diseases / complications*,  physiopathology,  radionuclide imaging*,  therapy
Humans
Iodobenzenes / diagnostic use*
Kaplan-Meiers Estimate
Kidney Diseases / complications*,  diagnosis
Male
Multivariate Analysis
Myocardium / pathology*
Prognosis
Risk
Thallium Radioisotopes / chemistry*
Tomography, Emission-Computed, Single-Photon
Treatment Outcome
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Iodobenzenes; 0/Thallium Radioisotopes; 116754-87-1/iodofiltic acid

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