Document Detail

Combining structural brain changes improves the prediction of Alzheimer's disease and mild cognitive impairment.
MedLine Citation:
PMID:  22759808     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Several structural brain changes have been associated with Alzheimer's disease (AD). This study investigated the prediction of AD by combining multiple brain changes with the hallmark medial temporal lobe atrophy (MTA).
METHODS: High-resolution magnetic resonance imaging (MRI) data of people with mild AD (n = 39), mild cognitive impairment (MCI; n = 82), and of healthy controls (HC; n = 58) were obtained at baseline. Among these people, 26 AD, 53 MCI, and 46 HC subjects had 24-month follow-up MRI scans. Bilateral MTA was evaluated using a medial temporal lobe atrophy scale (MTAS). Common changes in the aging brain were summarized using a brain atrophy and lesion index (BALI). The performance of the MTAS, BALI, and a score combining both, using a logistic regression model, were assessed.
RESULTS: The MTAS and BALI scores were closely correlated (r(2) > 0.56); each differed between the diagnostic groups. Having an unfavorable MTAS score was associated with an increased risk of MCI-AD conversion (OR = 3.71, p = 0.039), adjusted for age, sex, and education; having an unfavorable BALI score marginally contributed to such risks (OR = 4.08, p = 0.080). Combining MTAS and BALI components resulted in a greater OR (8.99, p = 0.007) and an improved predictive accuracy (75.9%, p = 0.002).
CONCLUSION: Multiple structural changes have an additive effect on AD. The data support potential future roles of combining multiple coexisting structural changes to benefit AD diagnosis, progression monitoring, and/or treatment effect evaluation.
Ningnannan Zhang; Xiaowei Song; Yunting Zhang;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2012-07-02
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  33     ISSN:  1421-9824     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-31     Completed Date:  2012-12-12     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  318-26     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
National Research Council Canada Institute for Biodiagnostics (Atlantic), Halifax, N.S., Canada.
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MeSH Terms
Aged, 80 and over
Aging / pathology
Alzheimer Disease / pathology*
Brain / pathology*
Case-Control Studies
Disease Progression
Magnetic Resonance Imaging
Middle Aged
Mild Cognitive Impairment / pathology*
Organ Size
Predictive Value of Tests
Sensitivity and Specificity
Temporal Lobe / pathology*
Grant Support
K01 AG030514/AG/NIA NIH HHS; P30 AG010129/AG/NIA NIH HHS; U01 AG024904/AG/NIA NIH HHS; U01 AG024904/AG/NIA NIH HHS

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