Document Detail

Combined valproate or carbamazepine and electroconvulsive therapy.
MedLine Citation:
PMID:  9167833     Owner:  NLM     Status:  MEDLINE    
This pharmacoepidemiological study was undertaken to determine if the combination of electroconvulsive therapy (ECT) and the anticonvulsants valproate (VPA) or carbamazepine (CBZ) is safe and efficacious. The charts of seven patients receiving ECT and VPA or CBZ (ECT-anticonvulsant group) concurrently between May 8, 1989, and May 9, 1993, were reviewed to determine the indication for each treatment, the number and type of ECT treatments, the seizure duration, adverse events, and the efficacy of the combination. The ECT-anticonvulsant group was compared to patients not treated with anticonvulsants (ECT-alone group) to determine if there were any differences in the two groups. Three patients had a marked clinical improvement, two a moderate response, one a minimal response, and one no response. The ECT-AC group, compared to the control group, had a shorter duration of seizures when unilateral treatments were used. However, there were no differences in the other variables compared. One patient had moderate confusion, and the other mild confusion and hypomania. This small case series suggests that the combination of ECT and anticonvulsants is safe and may be considered in patients for whom prophylaxis with anticonvulsant drugs is planned. Further controlled studies are needed to confirm our findings.
C A Zarate; M Tohen; G Baraibar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists     Volume:  9     ISSN:  1040-1237     ISO Abbreviation:  Ann Clin Psychiatry     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-07-16     Completed Date:  1997-07-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8911021     Medline TA:  Ann Clin Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  19-25     Citation Subset:  IM    
Pharmacoepidemiology Center, McLean Hospital, Belmont, Massachusetts 02178, USA.
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MeSH Terms
Aged, 80 and over
Anticonvulsants / administration & dosage,  adverse effects,  pharmacology*
Antimanic Agents / administration & dosage,  adverse effects,  pharmacology*
Bipolar Disorder / therapy*
Carbamazepine / administration & dosage,  adverse effects,  pharmacology*
Combined Modality Therapy
Confusion / etiology
Depressive Disorder / therapy*
Electroconvulsive Therapy* / adverse effects,  methods
Middle Aged
Seizures / prevention & control*
Treatment Outcome
Valproic Acid / administration & dosage,  adverse effects,  pharmacology*
Grant Support
Reg. No./Substance:
0/Anticonvulsants; 0/Antimanic Agents; 298-46-4/Carbamazepine; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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