| Combined use of propranolol and nifedipine offers better effects on portal vein nonuniform remodeling in carbon tetrachloride (CCl(4))-induced portal hypertensive rats. | |
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MedLine Citation:
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PMID: 19401196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Portal hypertension is a hemodynamic syndrome due to pathological increase in portal flow and portal pressure. These pathological changes in external flow loads will inevitably cause vascular remodeling in the portal vein, which is usually measured by an opening angle. The present study showed that carbon tetrachloride (CCl(4))-induced portal hypertension fully developed at 8 weeks and the opening angle of portal vein increased progressively in the pathogenesis of intrahepatic portal hypertension which was significantly augmented at 10 weeks. Although portal pressure and portal flow were reduced, treatment with either propranolol or nifedipine alone for 3 weeks did not decrease the augmented opening angle of the portal vein, while combined treatment with propranolol and nifedipine markedly reduced the increased opening angle of the portal vein and endothelial nitric oxide synthase (eNOS) mRNA expression but not inducible nitric oxide synthase (iNOS) mRNA expression. The decreasing effect of propranolol plus nifedipine on the elevated opening angle was significantly weakened by L-arginine and markedly reinforced by N-nitro-l-arginine-mythel-ester (L-NAME). These results indicate that combined use of propranolol and nifedipine ameliorates portal vein remodeling in portal hypertension at least by the nitric oxide-dependent way. |
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Authors:
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Zong-Qi Zhang; Bin Shi; Guo-Qiang Wu; Kai-Rong Qin; Zong-Lai Jiang; Liang Zhu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-03 |
Journal Detail:
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Title: European journal of pharmacology Volume: 613 ISSN: 1879-0712 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-01 Completed Date: 2009-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 108-13 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology,
therapeutic use Animals Calcium Channel Blockers / pharmacology, therapeutic use Carbon Tetrachloride / toxicity* Drug Combinations Drug Therapy, Combination Gene Expression Regulation, Enzymologic / drug effects Hemodynamics / drug effects Hypertension, Portal / chemically induced*, drug therapy, metabolism, physiopathology* Male Muscle, Smooth / drug effects, metabolism Nifedipine / pharmacology*, therapeutic use Nitric Oxide Synthase Type II / genetics Nitric Oxide Synthase Type III / genetics Portal Vein / drug effects*, physiopathology* Propranolol / pharmacology*, therapeutic use Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Calcium Channel Blockers; 0/Drug Combinations; 21829-25-4/Nifedipine; 525-66-6/Propranolol; 56-23-5/Carbon Tetrachloride; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nitric Oxide Synthase Type III |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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