Document Detail

Combined use of leg scanning and impedance plethysmography in suspected venous thrombosis. An alternative to venography.
MedLine Citation:
PMID:  865529     Owner:  NLM     Status:  MEDLINE    
Venography is the standard method for the diagnosis of venous thrombosis but is invasive and may cause discomfort. We evaluated the combination of impedance plethysmography and 125I-fibrinogen leg scanning as an alternative to venography in 200 symptomatic patients. One or both of these less invasive tests was positive in 81 of 86 patients with positive venograms (sensitivity of 94 per cent) and both were negative in 104 of 114 patients with negative venograms (specificity of 91 per cent). These two tests detected all 60 patients with popliteal or more proximal venous thrombosis and 21 of 26 patients with calf-vein thrombosis. In addition, this approach detected 21 of 22 patients with calf-vein thrombosis with symptoms for eight days or less. These results suggest that the combination of these two less invasive tests can be used as an alternative to venography in selected patients with clinically suspected venous thrombosis.
R Hull; J Hirsh; D L Sackett; P Powers; A G Turpie; I Walker
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The New England journal of medicine     Volume:  296     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-07-23     Completed Date:  1977-07-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1497-500     Citation Subset:  AIM; IM    
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MeSH Terms
False Negative Reactions
False Positive Reactions
Iodine Radioisotopes
Leg / blood supply*
Middle Aged
Plethysmography, Impedance*
Radionuclide Imaging*
Thrombophlebitis / diagnosis*,  radiography,  therapy
Reg. No./Substance:
0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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