Document Detail

Combined use of botulinum toxin type A and B for forehead rhytides: a randomized, double-blind, split-face study.
MedLine Citation:
PMID:  21801115     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This is the first well-controlled study of the combined use of botulinum toxin type A (BoNT-A) and botulinum toxin type B (BoNT-B) for hyperkinetic lines in forehead.
OBJECTIVE: To evaluate the effectiveness and safety of a mixture of BoNT-A and BoNT-B with that of equipotent BoNT-A alone for treating patients with forehead rhytides.
MATERIALS AND METHODS: Fourteen patients with forehead wrinkles completed this clinical study. On day 0, patients received a mixture of BoNT-A (5 U) and B (500 U) on one side of the forehead and BoNT-A (10 U) symmetrically on the other side. Clinical evaluation was made at the beginning and at weeks 1, 2, 4, 8, 12, and 16. Therapeutic efficacy was evaluated using clinical improvement scale by investigators and the subjective wrinkle assessment by patients.
RESULTS: According to investigator assessment, the differences between the average improvement scores of the two differently treated sides were not statistically significant at all follow-up visits. Moreover, the plateau of the clinical benefit was achieved at week 4.
CONCLUSION: We observed the equivalent efficacy in the mixture of both toxins and BoNT-A alone.
Jee-Woong Choi; Choon-Shik Youn; Hi-Tae An; Jong-Yeop Yoo; Jung-Im Na; Kyoung-Chan Park; Sang-Woong Youn; Chang-Hun Huh
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2011-07-31
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  24     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-07-17     Revised Date:  2013-11-25    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  England    
Other Details:
Languages:  eng     Pagination:  126-32     Citation Subset:  IM    
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MeSH Terms
Botulinum Toxins / therapeutic use*
Botulinum Toxins, Type A / therapeutic use*
Double-Blind Method
Drug Therapy, Combination
Middle Aged
Neuromuscular Agents / therapeutic use*
Skin Aging / drug effects*
Treatment Outcome
Reg. No./Substance:
0/Neuromuscular Agents; 0/incobotulinumtoxinA; 0Y70779M1F/rimabotulinumtoxinB; EC Toxins; EC Toxins, Type A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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