Document Detail

Combined tubular adenocarcinoma and hepatoid adenocarcinoma arising in Barrett esophagus.
MedLine Citation:
PMID:  20952273     Owner:  NLM     Status:  In-Data-Review    
Hepatoid adenocarcinoma arising in the esophagus is extremely rare. To date, there are only 3 cases in the world English literature. We report the fourth case here. A 76-year-old Japanese man was admitted to our hospital because of the deterioration of nephritic syndrome. He presented with chest burn, and the endoscopic examination of upper digestive tract disclosed the tumor in the lower esophagus. The subtotal esophagectomy was undertaken because of esophageal cancer. The postoperative histologic examination showed the finding of combined tubular adenocarcinoma and hepatoid adenocarcinoma arising in Barrett esophagus. Immunohistochemically, hepatoid adenocarcinoma cells were positive for a-fetoprotein, hepatocyte, a1-antitrypsin, a1-antichymotrypsin, and CDX2, but negative for MUC5AC and MUC6. Esophageal hepatoid adenocarcinoma seems to be closely associated with Barrett esophagus and show the intestinal phenotype rather than gastric phenotype.
Naoto Kuroda; Kazuhisa Onishi; Gang-Hong Lee
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Publication Detail:
Type:  Journal Article     Date:  2010-10-16
Journal Detail:
Title:  Annals of diagnostic pathology     Volume:  15     ISSN:  1532-8198     ISO Abbreviation:  Ann Diagn Pathol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9800503     Medline TA:  Ann Diagn Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  450-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi University, 780-8562 Kochi, Japan.
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