Document Detail


Combined tretinoin and glycolic acid treatment improves mouth opening for postburn patients.
MedLine Citation:
PMID:  16733782     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Postburn tissue repair progresses late, with changes in the skin's physical properties. Clinically, the skin appears dry, scaly, and dyschromic, with diminished elasticity, particularly in the presence of hypertrophic scars. Improvement of postburn skin can be obtained by using topical agents normally used in pathologies such as acne and photoaging. This study analyzed 77 patients, ages 6 to 46 years, with late perioral burn sequelae. The resulting integument was classified as grafted or restored when it epithelialized spontaneously. Topical treatment consisted of tretinoin (0.01-0.05%) and glycolic acid (5-7%) over a 3-month period. With the mouth opened maximally, the interdental (D) and interlabial (L) distances were measured using a digital caliper. Significant increases in D and L distances were observed after treatment, as compared with controls (p < 0.01). These results were similar in the restored and skin-grafted groups.
Authors:
Alessandra Grassi Salles; Rolf Gemperli; Paula Nunes Toledo; Marcus Castro Ferreira
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Aesthetic plastic surgery     Volume:  30     ISSN:  0364-216X     ISO Abbreviation:  Aesthetic Plast Surg     Publication Date:    2006 May-Jun
Date Detail:
Created Date:  2006-05-30     Completed Date:  2006-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7701756     Medline TA:  Aesthetic Plast Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  356-62     Citation Subset:  IM    
Affiliation:
Division of Plastic Surgery and Burns Unit, Hospital das Clínicas, School of Medicine, University of São Paulo, Brazil. agsalles@uol.com.br
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MeSH Terms
Descriptor/Qualifier:
Burns / therapy*
Glycolates / therapeutic use*
Humans
Keratolytic Agents / therapeutic use*
Masticatory Muscles / injuries
Mouth Diseases / drug therapy*,  etiology
Skin Transplantation*
Tretinoin / therapeutic use*
Chemical
Reg. No./Substance:
0/Glycolates; 0/Keratolytic Agents; 302-79-4/Tretinoin; 79-14-1/glycolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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