| Combined treatment with cytoprotective agents and radiotherapy. | |
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MedLine Citation:
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PMID: 20044209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Radiotherapy is associated with several toxicities affecting healthy tissues. One of the strategies aimed at decreasing radiation toxicity is the use of radioprotective agents, such as amifostine and palifermin, or factors stimulating hemopoetic stem cells (colony stimulating factors, CSFs): granulocyte-CSF, granulocyte macrophage-CSF and recombinant erythropoetins. The potential beneficial effect of these substances demonstrated in preclinical in vitro and in vivo studies led to numerous clinical trials. This review addresses the current experience on the use of cytoprotective agents in combination with radiotherapy, with particular focus on the safety of these approaches. Despite a relatively large body of literature data, the role of cytoprotective agents combined with radiotherapy remains controversial. Overall, their use in this application is still limited due to modest radioprotective effect for normal tissues, potential risk of tumor protection and increased treatment toxicity. The use of erythropoetins in combination with radiotherapy should generally be discouraged, whereas the safe and effective application of other agents warrants further investigations. |
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Authors:
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Piotr Winczura; Jacek Jassem |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-12-30 |
Journal Detail:
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Title: Cancer treatment reviews Volume: 36 ISSN: 1532-1967 ISO Abbreviation: Cancer Treat. Rev. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-12 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502030 Medline TA: Cancer Treat Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 268-75 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Oncology and Radiotherapy, Medical University of Gda?sk, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Combined Modality Therapy Hematologic Neoplasms / drug therapy*, radiotherapy* Humans Radiation-Protective Agents / therapeutic use* Radiotherapy* |
| Chemical | |
Reg. No./Substance:
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0/Radiation-Protective Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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