| Combined treatment with cyclophosphamide and prednisolone can induce remission of nephrotic syndrome in a patient with renal amyloidosis, associated with rheumatoid arthritis. | |
| | |
MedLine Citation:
|
PMID: 7923963 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A 67-year-old woman, who had been diagnosed with classical rheumatoid arthritis (RA), was admitted to our hospital because of massive proteinuria. Biopsy of the kidney revealed deposition of amyloid fibrils in the subepithelial and subendothelial spaces of the glomerular capillary walls. Though the treatment with prednisolone and dipyridamole against nephrotic syndrome and amyloidosis due to RA was not effective, cyclophosphamide, which was added after tapering of prednisolone, was able to induce remission of nephrotic syndrome after two years. The levels of CRP and serum amyloid A protein (SAA) returned to within the normal limits. As the impairment of renal function is thought to be due to deposition of amyloid supplied from the precursors of amyloid fibrils filtered from the general circulation in RA patients, remission of nephrotic syndrome might result from the suppression of production of SAA or removal of amyloid fibrils. Cyclophosphamide, which has the potential both to suppress disease activity in RA and to produce degradation of amyloid fibrils in glomeruli, may be useful against renal or systemic amyloidosis complicated by RA. |
| | |
Authors:
|
A Maezawa; K Hiromura; H Mitsuhashi; Y Tsukada; H Kanai; S Yano; T Naruse |
Related Documents
:
|
19603193 - Cytomegalovirus infection and haemophagocytosis in a patient with congenital nephrotic ... 7563953 - Histomorphometric study in children with idiopathic nephrotic syndrome. 22527553 - Vault prolapse of sigmoid neovagina 26 years after vaginoplasty in mayer-rokitansky-kü... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Clinical nephrology Volume: 42 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 1994 Jul |
Date Detail:
|
Created Date: 1994-11-18 Completed Date: 1994-11-18 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 30-2 Citation Subset: IM |
Affiliation:
|
Third Department of Internal Medicine, Gunma University School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Amyloidosis / drug therapy, etiology*, pathology Arthritis, Rheumatoid / complications* Cyclophosphamide / therapeutic use* Drug Therapy, Combination Female Humans Kidney / pathology Kidney Diseases / drug therapy, etiology*, pathology Nephrotic Syndrome / drug therapy*, etiology*, pathology Prednisolone / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
50-18-0/Cyclophosphamide; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Crescentic nephritis at Groote Schuur Hospital, South Africa--not a benign disease.
Next Document: Long-term evolution and growth patterns in a family with Bartter's syndrome.