Document Detail

Combined treatment of sudden sensorineural hearing loss with steroid, dextran and piracetam: experience with 68 cases.
MedLine Citation:
PMID:  12937918     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to evaluate the effectiveness of our combined treatment regimen and to clarify the possible prognostic factors in sudden sensorineural hearing loss (SSNHL). In a retrospective chart review, the charts of 68 patients who matched the inclusion criteria of this study were evaluated. All patients were treated with a standard regimen including prednisone, dextran and piracetam between January 1998 and December 2001. Initial (at the beginning of therapy) and final (3 weeks after the beginning of therapy) audiograms were compared with respect to hearing improvement. Possible prognostic factors were also evaluated. Overall hearing improvement was determined as 54.4%. Sex was the only determined prognostic factor in this study. Females had a better prognosis. Our treatment regimen had no superiority to the reported spontaneous hearing recovery. Females seem to have a better prognosis.
Erdal Samim; Rahmi Kilic; Ali Ozdek; Hakan Gocmen; Adil Eryilmaz; Ilhan Unlu
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Publication Detail:
Type:  Journal Article     Date:  2003-08-22
Journal Detail:
Title:  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery     Volume:  261     ISSN:  0937-4477     ISO Abbreviation:  Eur Arch Otorhinolaryngol     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-22     Completed Date:  2004-09-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9002937     Medline TA:  Eur Arch Otorhinolaryngol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  187-90     Citation Subset:  IM    
Department of Ear, Nose and Throat, Ministry of Health Research and Training Hospital, Ankara, Turkey.
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MeSH Terms
Administration, Oral
Age Factors
Aged, 80 and over
Dextrans / administration & dosage*
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Therapy, Combination
Follow-Up Studies
Hearing Loss, Sensorineural / diagnosis,  drug therapy*
Hearing Loss, Sudden / diagnosis,  drug therapy*
Infusions, Intravenous
Middle Aged
Piracetam / administration & dosage*
Prednisone / administration & dosage*
Retrospective Studies
Risk Assessment
Severity of Illness Index
Sex Factors
Treatment Outcome
Reg. No./Substance:
53-03-2/Prednisone; 7491-74-9/Piracetam; 9004-54-0/Dextrans

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