| Combined transcranial Doppler and EEG recording in vasovagal syncope. | |
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MedLine Citation:
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PMID: 18756091 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In neurally mediated syncope a 'typical' EEG pattern during hyperventilation (HV) may be observed. This study aimed to investigate transcranial Doppler (TCD) and EEG variations in response to hyper- and hypocapnia using simultaneous recording. METHODS: Syncope patients with a typical EEG pattern during HV (SEEG+, n = 15) and those without abnormalities (SEEG-, n = 16) were compared with healthy controls (n = 20). Simultaneous TCD and EEG recordings were performed at rest (baseline), during 2 apnea tests and during HV. Cerebrovascular vasoreactivity, index for hypocapnia, total vasomotor reserve and time to flow velocity normalization after HV (t-norm) were recorded. RESULTS: With TCD, a reduction in Vasomotor reserve was observed in SEEG+ compared with the other 2 groups (control: 67 +/- 8%; SEEG-: 67 +/- 10%; SEEG+: 57 +/- 8%; p < 0.0001). t-norm was longer in all syncopal patients and in particular in SEEG+ (control: 20.2 +/- 3 s; SEEG-: 40 +/- 7 s; SEEG+: 123 +/- 45s; p < 0.0001). Quantitative EEG showed an increase in slow bands in all subjects during HV, small and nonsignificant in controls and SEEG-, higher and significant in SEEG+, related with flow reduction. CONCLUSIONS: Changes in the sympathetic modulation of cerebral vasoconstriction may explain both the pathophysiology of vasovagal syncope and the typical paroxysmal EEG findings. |
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Authors:
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E Vicenzini; S Pro; S Strano; P Pulitano; M Altieri; V Di Piero; G L Lenzi; N Accornero; O Mecarelli |
Publication Detail:
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Type: Journal Article Date: 2008-08-29 |
Journal Detail:
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Title: European neurology Volume: 60 ISSN: 1421-9913 ISO Abbreviation: Eur. Neurol. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-10-15 Completed Date: 2008-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0150760 Medline TA: Eur Neurol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 258-63 Citation Subset: IM |
Copyright Information:
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Copyright 2008 S. Karger AG, Basel. |
Affiliation:
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Department of Neurological Sciences, University of Rome, 'La Sapienza', Rome, Italy. edoardo.vicenzini@uniroma1.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Brain / physiopathology* Electroencephalography* Female Humans Hypercapnia / physiopathology, ultrasonography Hypocapnia / physiopathology, ultrasonography Male Syncope, Vasovagal / physiopathology*, ultrasonography* Ultrasonography, Doppler, Transcranial* |
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