| Combined endurance/resistance training reduces plasma TNF-alpha receptor levels in patients with chronic heart failure and coronary artery disease. | |
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MedLine Citation:
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PMID: 12445534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Physical reconditioning of patients with chronic heart failure (CHF) improves exercise capacity and restores endothelial function and skeletal muscle changes. The effects of 4 months combined endurance/resistance exercise training on cytokines and cytokine receptors in patients with CHF were studied. In addition, changes in submaximal and maximal exercise performance were addressed. METHODS AND RESULTS: Twenty-three patients with stable CHF due to coronary artery disease (CAD, n=12) or idiopathic dilated cardiomyopathy (IDCM, n=11) were trained for 4 months. Blood sampling for measurement of plasma concentrations (ELISA) of interleukin (IL)-6, tumour necrosis factor (TNF)-alpha, soluble TNF receptor 1 (sTNFR1) and 2 (sTNFR2), as well as cardiopulmonary exercise testing were performed at baseline and after 4 months. Training induced a significant decrease in sTNFR1 (P=0.02) for the total population, and in both sTNFR1 (P=0.01) and sTNFR2 (P=0.02) concentrations for the CAD group only. IL-6 and TNF-alpha levels were not altered. Cytokine concentrations remained unchanged in an untrained age- and sex-matched control group. NYHA functional class, submaximal and maximal workrate were significantly improved in both patient groups. Oxygen uptake at the anaerobic threshold (P=0.002) and at peak exercise increased in the CAD patients only (P=0.008). CONCLUSION: Besides an overall beneficial effect on exercise capacity, combined endurance/resistance exercise training has an anti-inflammatory effect in patients with CHD and CAD. |
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Authors:
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V M Conraads; P Beckers; J Bosmans; L S De Clerck; W J Stevens; C J Vrints; D L Brutsaert |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European heart journal Volume: 23 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-26 Completed Date: 2003-04-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 1854-60 Citation Subset: IM |
Copyright Information:
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Copyright 2002 The European Society of Cardiology. Published by Elsevier Science Ltd. |
Affiliation:
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Department of Cardiology, University Hospital Antwerp (UIA), Wilrijkstraat 10, 2650 Edegem, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Coronary Disease / blood, rehabilitation* Cytokines / blood Exercise Therapy / methods* Exercise Tolerance Female Heart Failure / blood, rehabilitation* Humans Interleukin-6 / blood Male Middle Aged Oxygen Consumption Physical Endurance Receptors, Tumor Necrosis Factor / blood* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukin-6; 0/Receptors, Tumor Necrosis Factor |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 2002 Dec;23(23):1803-4
[PMID:
12445529
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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