Document Detail

Combined therapy in the treatment of hypertension.
MedLine Citation:
PMID:  19682088     Owner:  NLM     Status:  MEDLINE    
The majority of patients with hypertension need at least two antihypertensive agents to achieve blood pressure (BP) objectives. As current European guidelines for the treatment of arterial hypertension recommend, combined therapy is required when monotherapy fails and as a first-line treatment in certain situations, such as subjects at high or very high cardiovascular risk, markedly elevated BP values, or when lower targets are required (<130/80 mmHg). The advantages of combined therapy are well known and include an earlier and higher antihypertensive efficacy because of complementary mechanisms of action, and a lower incidence of side effects due to the possible compensatory responses and, in many cases, the lower doses used. In the present study, available evidence about the efficacy and tolerability of combined therapy for the treatment of hypertension is updated.
Carlos Escobar; Vivencio Barrios
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-08-14
Journal Detail:
Title:  Fundamental & clinical pharmacology     Volume:  24     ISSN:  1472-8206     ISO Abbreviation:  Fundam Clin Pharmacol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-05-12     Completed Date:  2010-08-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710411     Medline TA:  Fundam Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3-8     Citation Subset:  IM    
Department of Cardiology, Hospital Infanta Sofia, Madrid, Spain.
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MeSH Terms
Antihypertensive Agents / administration & dosage,  adverse effects,  therapeutic use*
Blood Pressure / drug effects*
Cardiovascular Diseases / etiology,  prevention & control
Drug Therapy, Combination
Hypertension / complications,  drug therapy*
Practice Guidelines as Topic
Risk Factors
Treatment Outcome
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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