| Combined therapy in the treatment of hypertension. | |
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MedLine Citation:
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PMID: 19682088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The majority of patients with hypertension need at least two antihypertensive agents to achieve blood pressure (BP) objectives. As current European guidelines for the treatment of arterial hypertension recommend, combined therapy is required when monotherapy fails and as a first-line treatment in certain situations, such as subjects at high or very high cardiovascular risk, markedly elevated BP values, or when lower targets are required (<130/80 mmHg). The advantages of combined therapy are well known and include an earlier and higher antihypertensive efficacy because of complementary mechanisms of action, and a lower incidence of side effects due to the possible compensatory responses and, in many cases, the lower doses used. In the present study, available evidence about the efficacy and tolerability of combined therapy for the treatment of hypertension is updated. |
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Authors:
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Carlos Escobar; Vivencio Barrios |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-08-14 |
Journal Detail:
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Title: Fundamental & clinical pharmacology Volume: 24 ISSN: 1472-8206 ISO Abbreviation: Fundam Clin Pharmacol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-05-12 Completed Date: 2010-08-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710411 Medline TA: Fundam Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 3-8 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Hospital Infanta Sofia, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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administration & dosage,
adverse effects,
therapeutic use* Blood Pressure / drug effects* Cardiovascular Diseases / etiology, prevention & control Drug Therapy, Combination Europe Humans Hypertension / complications, drug therapy* Practice Guidelines as Topic Risk Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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