Document Detail

Combined thalidomide and cyclophosphamide treatment for refractory or relapsed multiple myeloma patients: a prospective phase II study.
MedLine Citation:
PMID:  15605244     Owner:  NLM     Status:  MEDLINE    
Thalidomide is an effective agent for patients with refractory multiple myeloma (MM) with a response rate of 30-40% at doses of 200-800 mg but with considerable side effects. We questioned whether lower doses of thalidomide in combination with a daily dose of cyclophosphamide might be an effective regimen with fewer side effects. We included 38 patients with relapsed or refractory MM. The median doses of thalidomide and cyclophosphamide were 100 and 95 mg/day, respectively. Side effects were observed in all patients, with neurotoxicity as the most troublesome. With a median follow-up of 14 months 84% of the patients responded, including 64% partial responses. The median time of progression-free survival was 30 months and the median overall survival time was 20 months. In conclusion, the results demonstrate that the combination of low-dose thalidomide with a daily dose of cyclophosphamide is an effective regimen with a high overall response rate and manageable side effects.
Sjoerd Hovenga; Simon M G J Daenen; Joost T M de Wolf; Gustaaf W van Imhoff; Hanneke C Kluin-Nelemans; Wim J Sluiter; Edo Vellenga
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-12-17
Journal Detail:
Title:  Annals of hematology     Volume:  84     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-01     Completed Date:  2005-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  311-6     Citation Subset:  IM    
Department of Haematology, University Hospital Groningen, P.O. Box 30.001, 9700, Groningen, The Netherlands.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*,  toxicity
Cyclophosphamide / administration & dosage,  toxicity
Disease-Free Survival
Dose-Response Relationship, Drug
Drug Therapy, Combination
Immunosuppressive Agents / administration & dosage,  toxicity
Multiple Myeloma / mortality,  prevention & control*
Thalidomide / administration & dosage,  toxicity
Reg. No./Substance:
0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide; 50-35-1/Thalidomide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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