Document Detail

Combined status of MUC1 mucin and surfactant apoprotein A expression can predict the outcome of patients with small-size lung adenocarcinoma.
MedLine Citation:
PMID:  14764058     Owner:  NLM     Status:  MEDLINE    
AIM: Lung cancer is still a disease of high mortality, despite advanced diagnostic techniques. Here, we aim to report a unique method to predict the recurrence and outcome of patients with pulmonary adenocarcinomas. METHODS AND RESULTS: Immunohistochemical expression of MUC1 mucin and surfactant apoprotein A (SP-A) was examined in 185 cases of surgically removed lung adenocarcinomas of non-bronchioloalveolar type smaller than 30 mm. Staining results were evaluated semiquantitatively, and the expression of MUC1 and SP-A was compared in each case. There were 140/185 (76%) cases showing MUC1 expression higher than SP-A expression (MUC1>SP-A), and 45/185 (24%) cases showing MUC1 expression lower than or equal to SP-A expression (MUC1<or =SP-A). Recurrence was observed in 24% (34/140) of the patients with a MUC1>SP-A pattern, but in 7% (3/45) of the patients with a MUC1< or =SP-A pattern after the median observation period of 41 months (1-99 months) (P < 0.01). The MUC1>SP-A group showed higher recurrence and worse survival than the MUC1<or =SP-A group by Kaplan-Meier's method (P < 0.01 and P < 0.005). Even in the patients with apparently favourable prognostic factors (well-differentiated adenocarcinoma or no lymph node metastasis), recurrence and survival were different between the two groups. CONCLUSIONS: A high MUC1/SP-A ratio is strongly associated with a poor outcome in patients with small-size lung adenocarcinoma.
H Tsutsumida; M Goto; S Kitajima; I Kubota; Y Hirotsu; S Yonezawa
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Histopathology     Volume:  44     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-06     Completed Date:  2004-09-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  147-55     Citation Subset:  IM    
Division of Human Pathology, Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
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MeSH Terms
Adenocarcinoma / metabolism*,  mortality,  pathology
Aged, 80 and over
Apoproteins / biosynthesis*
Disease-Free Survival
Lung Neoplasms / metabolism*,  mortality,  pathology
Lymphatic Metastasis / pathology
Middle Aged
Mucin-1 / biosynthesis*
Neoplasm Recurrence, Local / metabolism
Pulmonary Surfactant-Associated Proteins / biosynthesis*
Tumor Markers, Biological / analysis*
Reg. No./Substance:
0/Apoproteins; 0/Mucin-1; 0/Pulmonary Surfactant-Associated Proteins; 0/Tumor Markers, Biological; 0/pulmonary surfactant apoprotein

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