Document Detail

Combined signet ring cell and glassy cell carcinoma of the uterine cervix arising in a young Japanese woman: a case report with immunohistochemical and histochemical analyses.
MedLine Citation:
PMID:  15482569     Owner:  NLM     Status:  MEDLINE    
Signet ring cell carcinoma and glassy cell carcinoma are both rare histological subtypes of uterine cervical cancer. This report is of a case of uterine cervical carcinoma arising in a 29-year-old woman who had major components of signet ring cell carcinoma and glassy cell carcinoma within the same tumor. Histochemical and immunohistochemical analyses, including high and low molecular weight cytokeratins, p63 and MUC5AC, additionally demonstrated the squamous and adenocarcinomatous differentiation in the neoplastic cells, which showed otherwise unclassifiable morphology on the haematoxylin-eosin sections. A wide range of differentiation described above supports the speculation that glassy cell carcinoma may arise from the multipotential immature cells that can differentiate into both squamous and glandular cells. It would be precise to classify this tumor as adenosquamous carcinoma. Although adenosquamous carcinoma is not a rare histological subtype in the uterine cervix, it should be necessary to report the presence of glassy cells and signet ring cells when present because the presence of both components is associated with an unfavorable clinical behavior.
Suzuko Moritani; Shu Ichihara; Ryoji Kushima; Fumiyoshi Sugiura; Masafumi Mushika; Steven G Silverberg
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pathology international     Volume:  54     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-14     Completed Date:  2005-02-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  787-92     Citation Subset:  IM    
Department of Pathology, Nagoya National Hospital, Nagoya, Japan.
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MeSH Terms
Carcinoma, Adenosquamous / metabolism,  pathology*,  therapy
Carcinoma, Signet Ring Cell / metabolism,  pathology*,  therapy
Chemotherapy, Adjuvant
DNA-Binding Proteins
Genes, Tumor Suppressor
Keratins / metabolism
Mucin 5AC
Mucins / metabolism
Neoplasms, Multiple Primary / metabolism,  pathology*
Phosphoproteins / metabolism
Trans-Activators / metabolism
Treatment Outcome
Tumor Markers, Biological / metabolism
Tumor Suppressor Proteins
Uterine Cervical Neoplasms / metabolism,  pathology*,  therapy
Reg. No./Substance:
0/DNA-Binding Proteins; 0/MUC5AC protein, human; 0/Mucin 5AC; 0/Mucins; 0/Phosphoproteins; 0/TP63 protein, human; 0/Trans-Activators; 0/Tumor Markers, Biological; 0/Tumor Suppressor Proteins; 68238-35-7/Keratins

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