| Combined signet ring cell and glassy cell carcinoma of the uterine cervix arising in a young Japanese woman: a case report with immunohistochemical and histochemical analyses. | |
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MedLine Citation:
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PMID: 15482569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Signet ring cell carcinoma and glassy cell carcinoma are both rare histological subtypes of uterine cervical cancer. This report is of a case of uterine cervical carcinoma arising in a 29-year-old woman who had major components of signet ring cell carcinoma and glassy cell carcinoma within the same tumor. Histochemical and immunohistochemical analyses, including high and low molecular weight cytokeratins, p63 and MUC5AC, additionally demonstrated the squamous and adenocarcinomatous differentiation in the neoplastic cells, which showed otherwise unclassifiable morphology on the haematoxylin-eosin sections. A wide range of differentiation described above supports the speculation that glassy cell carcinoma may arise from the multipotential immature cells that can differentiate into both squamous and glandular cells. It would be precise to classify this tumor as adenosquamous carcinoma. Although adenosquamous carcinoma is not a rare histological subtype in the uterine cervix, it should be necessary to report the presence of glassy cells and signet ring cells when present because the presence of both components is associated with an unfavorable clinical behavior. |
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Authors:
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Suzuko Moritani; Shu Ichihara; Ryoji Kushima; Fumiyoshi Sugiura; Masafumi Mushika; Steven G Silverberg |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pathology international Volume: 54 ISSN: 1320-5463 ISO Abbreviation: Pathol. Int. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-10-14 Completed Date: 2005-02-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9431380 Medline TA: Pathol Int Country: Australia |
Other Details:
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Languages: eng Pagination: 787-92 Citation Subset: IM |
Affiliation:
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Department of Pathology, Nagoya National Hospital, Nagoya, Japan. MoritaniS@aol.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carcinoma, Adenosquamous / metabolism, pathology*, therapy Carcinoma, Signet Ring Cell / metabolism, pathology*, therapy Chemotherapy, Adjuvant DNA-Binding Proteins Female Genes, Tumor Suppressor Humans Immunohistochemistry Keratins / metabolism Mucin 5AC Mucins / metabolism Neoplasms, Multiple Primary / metabolism, pathology* Phosphoproteins / metabolism Trans-Activators / metabolism Treatment Outcome Tumor Markers, Biological / metabolism Tumor Suppressor Proteins Uterine Cervical Neoplasms / metabolism, pathology*, therapy |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/MUC5AC protein, human; 0/Mucin 5AC; 0/Mucins; 0/Phosphoproteins; 0/TP63 protein, human; 0/Trans-Activators; 0/Tumor Markers, Biological; 0/Tumor Suppressor Proteins; 68238-35-7/Keratins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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