| Combined positron emission tomography-computed tomography and tumor markers for detecting recurrent ovarian cancer. | |
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MedLine Citation:
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PMID: 20221620 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the accuracy of integrated FDG-PET/CT and tumor markers for the depiction of recurrent ovarian carcinoma. METHODS: Patients with pathologically proven ovarian cancer, who underwent cytoreductive surgery and 3-6 cycles of adjuvant chemotherapy, were included in this study. They all underwent a thorough physical examination, tumor marker determination, and FDG-PET/CT imaging. The sensitivity, specificity, accuracy, and positive and negative predictive values for the tumor detection with PET/CT versus different tumor markers were performed in relation to the results at histological analysis after second-look surgery or clinical follow-up. RESULTS: A total of 37 patients underwent FDG-PET/CT scans. Among them, 22 patients underwent exploratory laparotomy and 15 had diagnostic laparoscopy. Overall, 24 patients were documented to have ovarian cancer recurrence after second operation. FDG-PET/CT had sensitivity, specificity, accuracy, and positive and negative predictive values of 100, 85, 94, 92, and 100%, respectively. CONCLUSION: Our study has shown that PET/CT is a sensitive tool to assist in the early identification and recurrent ovarian cancer, amenable to secondary cytoreduction. |
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Authors:
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Hun-Shan Pan; Shiow-Lin Lee; Lee-Wen Huang; Yen-Kung Chen |
Publication Detail:
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Type: Journal Article Date: 2010-03-11 |
Journal Detail:
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Title: Archives of gynecology and obstetrics Volume: 283 ISSN: 1432-0711 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: Germany |
Other Details:
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Languages: eng Pagination: 335-41 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Shin-Kong Wu-Ho-Su Memorial Hospital, No 95, Wen-Chang Road, Shih-Lin District, Taipei, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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