Document Detail


Combined phenotypic and genotypic analysis of ringed sideroblasts in acquired idiopathic sideroblastic anemia.
MedLine Citation:
PMID:  3933247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bone marrow from an 81-year-old male with acquired idiopathic sideroblastic anemia was found to be mosaic for 45,X/46,XY cell lines. Analysis of ringed sideroblasts for the presence or absence of a quinicrine fluorescent Y body indicated that all sideroblastic cells had lost the Y chromosome. The demonstration that the ringed sideroblasts were cytogenetically abnormal in this patient provides evidence that the cytogenetic changes often found in patients with sideroblastic anemia may not be due to randomly acquired chromosome aberrations accompanying tissue aging unrelated to the disease process.
Authors:
D D Bennett; W S Stanley; C B Johnson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta haematologica     Volume:  73     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-12-12     Completed Date:  1985-12-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  235-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Anemia, Sideroblastic / genetics*
Bone Marrow Examination
Chromosome Aberrations
Erythrocytes / cytology*
Genotype
Humans
Karyotyping
Male
Phenotype
Y Chromosome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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