| Combined nattokinase with red yeast rice but not nattokinase alone has potent effects on blood lipids in human subjects with hyperlipidemia. | |
| | |
MedLine Citation:
|
PMID: 19786378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The purpose of this randomized, double-blind, placebo-controlled, parallel comparison study was to evaluate the lipid-lowering effect of orally administrated nattokinase and nattokinase combined with red yeast rice (RYR) extract on blood lipids in patients with hyperlipidemia. A total of 47 patients with hyperlipidemia were assigned to one of three groups: 1. nattokinase-mono formula (50 mg/capsule), 2. combined formula of nattokinase with RYR (300 mg of extract/capsule) and 3. placebo. Subjects received a twice daily dose of two capsules for six months. The mono formula showed no effects on blood lipids until month six, while the combined formula ameliorated all of measured lipids starting from month one. In the combined group significant decreases were found with regard to: triglycerides (TG) by 15%, total cholesterol (TC) by 25%, low-density lipoprotein cholesterol (LDL-C) by 41%, TC/high-density lipoprotein cholesterol (HDL-C) ratio by 29.5%, and increases in HDL-C by 7.5%. These changes were sustained until the end of study. After controlling for baseline levels, only the combined group, but not mono group, showed a significant difference (p<0.0001) in TC, LDL-C and TC/HDL-C ratio when compared with the placebo group. In summary, this study provides long-term efficacy of nattokinase supplementation and shows that the combined formula has relatively more potent effects than the mono formula on lowering of blood lipids, suggesting that combined nattokinase with RYR will be a better neutraceutical for patients with hyperlipidemia than nattokinase alone. |
| | |
Authors:
|
Nae-Cherng Yang; Chien-Wen Chou; Chung-Yin Chen; Kai-Lin Hwang; Yi-Chueh Yang |
Related Documents
:
|
7934538 - Effect on coronary atherosclerosis of decrease in plasma cholesterol concentrations in ... 20583538 - Adiposity, physical activity and blood lipid profile in 13-year-old adolescents. 21539488 - Diet and alzheimer's disease risk factors or prevention: the current evidence. 10807748 - Common polymorphism in promoter of microsomal triglyceride transfer protein gene influe... 16150838 - Heat stress increases apical glucose transport in the chicken jejunum. 7619858 - Effects of interactions of apolipoprotein a-ii with apolipoproteins a-i or a-iv on [3h]... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Asia Pacific journal of clinical nutrition Volume: 18 ISSN: 0964-7058 ISO Abbreviation: Asia Pac J Clin Nutr Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-09-29 Completed Date: 2009-12-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9440304 Medline TA: Asia Pac J Clin Nutr Country: Australia |
Other Details:
|
Languages: eng Pagination: 310-7 Citation Subset: IM |
Affiliation:
|
Department of Nutrition and Health Science, Chungchou Institute of Technology, Changhua 510, Taiwan. naeboy@dragon.ccut.edu.tw. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT00749801 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Anticholesteremic Agents / adverse effects, therapeutic use* Biological Products / adverse effects, therapeutic use* Dietary Supplements* / adverse effects Double-Blind Method Female Humans Hyperlipidemias / therapy* Kidney Function Tests Lipids / blood Liver Function Tests Male Middle Aged Subtilisins / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Anticholesteremic Agents; 0/Biological Products; 0/Lipids; 0/red yeast rice; EC 3.4.21.-/Subtilisins; EC 3.4.21.-/nattokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The development of a national salt reduction strategy for Australia.
Next Document: Serum lutein and its dynamic changes during supplementation with lutein in Chinese subjects.