| Combined modality treatment for patients with locally advanced pancreatic adenocarcinoma. | |
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MedLine Citation:
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PMID: 22648697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Radiofrequency ablation (RFA) is an emerging treatment for patients with locally advanced pancreatic carcinoma, and can be combined with radiochemotherapy and intra-arterial plus systemic chemotherapy. METHODS: This observational study compared two groups of patients with locally advanced pancreatic carcinoma treated with either primary RFA (group 1) or RFA following any other primary treatment (group 2). RESULTS: Between February 2007 and May 2010, 107 consecutive patients were treated with RFA. There were 47 patients in group 1 and 60 in group 2. Median overall survival was 25·6 months. Median overall survival was significantly shorter in group 1 than in group 2 (14·7 versus 25·6 months; P = 0·004) Patients treated with RFA, radiochemotherapy and intra-arterial plus systemic chemotherapy (triple-approach strategy) had a median overall survival of 34·0 months. CONCLUSION: RFA after alternative primary treatment was associated with prolonged survival. This was further extended by use of a triple-approach strategy in selected patients. Further evaluation of this approach seems warranted. |
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Authors:
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M Cantore; R Girelli; A Mambrini; I Frigerio; G Boz; R Salvia; A Giardino; M Orlandi; A Auriemma; C Bassi |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2012-05-30 |
Journal Detail:
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Title: The British journal of surgery Volume: 99 ISSN: 1365-2168 ISO Abbreviation: Br J Surg Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-07-10 Completed Date: 2012-09-24 Revised Date: 2013-06-03 |
Medline Journal Info:
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Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: England |
Other Details:
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Languages: eng Pagination: 1083-8 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. |
Affiliation:
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Oncological Department, Carrara Hospital, Carrara, Italy. maurizio.cantore@usl1.toscana.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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therapy* Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Catheter Ablation / adverse effects, methods* Chemoradiotherapy / methods* Cisplatin / administration & dosage Combined Modality Therapy Deoxycytidine / administration & dosage, analogs & derivatives Epirubicin / administration & dosage Female Humans Kaplan-Meier Estimate Male Middle Aged Pancreatic Neoplasms / therapy* Postoperative Complications / etiology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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15663-27-1/Cisplatin; 56420-45-2/Epirubicin; 951-77-9/Deoxycytidine; B76N6SBZ8R/gemcitabine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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