| Combined metformin and clomiphene citrate versus highly purified FSH for ovulation induction in clomiphene-resistant PCOS women: a randomised controlled trial. | |
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MedLine Citation:
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PMID: 20568955 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aim.?To compare the effect of combined metformin?clomiphene citrate (CC) with highly purified urinary FSH (HP-uFSH) for ovulation induction in CC-resistant women with polycystic ovary syndrome (PCOS). Methods.?One-hundred fifty-three anovulatory women with CC-resistant PCOS were selected in this randomised controlled trial. Patients received combined metformin?CC (n?=?75, 205 cycles) or HP-uFSH (n?=?78, 186 cycles) for three cycles. Outcome measures were; Ovulation rate, number of growing and mature follicles, serum E2, serum P, endometrial thickness, pregnancy and miscarriage rates. Results.?The ovulation rate per cycle was significantly higher in the HP-uFSH group (83.8% vs. 62%, p?=?0.01). The number of follicles ?12?mm ?14?mm and ?18?mm on the hCG day was significantly greater in the HP-uFSH group (p?=?0.01, p?=?0.02 and p?=?0.03, respectively). Pregnancy occurred in 23/205 cycles (11.2%) in combined metformin?CC group and 40/186 cycles (21.5%) in the HP-uFSH group; the difference was statistically significant (p?=?0.02). Two patients in the HP-uFSH group suffered mild OHSS. Conclusions.?Combined metformin?CC resulted in modest ovulation and pregnancy rates without side effects. It is logical to offer this first for CC-resistant PCOS women before resorting to more expensive alternatives especially in developing communities where economic aspects of therapy are important. |
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Authors:
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Hatem Abu Hashim; Alaa Wafa; Mohamed El Rakhawy |
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Publication Detail:
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Type: Journal Article Date: 2010-06-23 |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 27 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 190-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Mansoura University, Mansoura, Egypt. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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