Document Detail


Combined measurement of PEDF, haptoglobin and tau in cerebrospinal fluid improves the diagnostic discrimination between alzheimer's disease and other dementias.
MedLine Citation:
PMID:  21323605     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Using proteomic approach in cerebrospinal fluid (CSF) we identified pigment epithelium-derived factor (PEDF) and Haptoglobin (Hp) as putative markers that could discriminate between AD and other dementias. ELISA assays were developed to measure the levels of PEDF and Hp in CSF from patients with AD (AD, n = 27), non-AD (NAD, n = 30) and in non-demented patients (ND, n = 27). The combined assessment of PEDF, Hp and Tau levels, using Iterative Marginal Optimization, improved the differential diagnosis of AD, especially in patients with moderate to severe dementia (p<0.002). This pilot study highlights the probable different contribution of oxidative mechanisms in dementia.
Authors:
Jean-Daniel Abraham; Sophie Calvayrac-Pawlowski; Sandra Cobo; Nicolas Salvetat; Guillaume Vicat; Laurence Molina; Jacques Touchon; Bernard-François Michel; Franck Molina; Jean-Michel Verdier; Jeannette Fareh; Chantal Mourton-Gilles
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  16     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  161-71     Citation Subset:  IM    
Affiliation:
SysDiag CNRS / Bio-Rad UMR3145, 1682 rue de la Valsiere, Montpellier, France.
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