Document Detail

Combined magnification endoscopy with chromoendoscopy in the evaluation of patients with suspected malabsorption.
MedLine Citation:
PMID:  9378209     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Magnification endoscopy and chromoendoscopy together have been used to evaluate mucosal detail in a number of conditions, including Barrett's esophagus and flat colonic polyps, but they have not been used to evaluate villous atrophy in the proximal small intestine. METHODS: Thirty-four patients suspected of having a malabsorption syndrome (either celiac disease or tropical sprue) were evaluated using an Olympus magnification gastroscope in both normal and high magnification settings. Indigo carmine dye spraying techniques were used to assist in evaluating duodenal mucosa for evidence of villous atrophy. The accuracy of endoscopically predicted villous atrophy was assessed by histologic evaluation of biopsy specimens taken in the descending duodenum. RESULTS: Magnification endoscopy with dye spraying was both highly sensitive (94%) and specific (88%) in identifying patients with villous atrophy. This technique was more accurate (91%) in identifying patients with partial atrophy than standard endoscopy (9%, p < 0.01) and was also useful in identifying patients with patchy villous atrophy (5 of 5) to allow directed biopsies of abnormal tissue. CONCLUSION: Magnification endoscopy with chromoendoscopy is a promising technique for the evaluation of patients with suspected malabsorption. This technique is especially valuable in patients with partial atrophy, where villous abnormalities can be patchy and the duodenum usually appears normal during standard endoscopy.
L M Siegel; P D Stevens; C J Lightdale; P H Green; S Goodman; R J Garcia-Carrasquillo; H Rotterdam
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Gastrointestinal endoscopy     Volume:  46     ISSN:  0016-5107     ISO Abbreviation:  Gastrointest. Endosc.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-11-07     Completed Date:  1997-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0010505     Medline TA:  Gastrointest Endosc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  226-30     Citation Subset:  IM    
Department of Medicine, Columbia-Presbyterian Medical Center, New York, NY 10032, USA.
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MeSH Terms
Barrett Esophagus / complications
Colonic Polyps / complications
Coloring Agents / diagnostic use
Duodenum / pathology
Endoscopy, Digestive System / methods*
Intestinal Mucosa / pathology*
Malabsorption Syndromes / diagnosis*,  etiology,  pathology
Predictive Value of Tests
Video Recording
Reg. No./Substance:
0/Coloring Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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